The Antitumor Efficacy of β -Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment

BioMed Research International
Qiang XieChundong Gu

Abstract

Inflammatory mediators and inflammatory cells in the inflammatory microenvironment promote the transformation of normal cells to cancer cells in the early stage of cancer, promote the growth and development of cancer cells, and induce tumor immune escape. The monomeric active ingredient β-elemene is extracted from the traditional Chinese medicine Curcuma wenyujin and has been proven to have good anti-inflammatory and antitumor activities in clinical applications for more than 20 years in China. Recent studies have found that this traditional Chinese medicine plays a vital role in macrophage infiltration and M2 polarization, as well as in regulating immune disorders, and it even regulates the transcription factors NF-κB and STAT3 to alter inflammation, tumorigenesis, and development. In addition, β-elemene regulates not only different inflammatory factors (such as TNF-α, IFN, TGF-β, and IL-6/10) but also oxidative stress in vivo and in vitro. The excellent anti-inflammatory and antitumor effects of β-elemene and its ability to alter the inflammatory microenvironment of tumors have been gradually elaborated. Although the study of monomeric active ingredients in traditional Chinese medicines is insufficient in terms of quality and...Continue Reading

References

May 9, 2002·American Journal of Physiology. Cell Physiology·Aïssata AmadouFrançoise Pecker
Jul 16, 2008·Journal of Cellular and Molecular Medicine·Germán AndrésMarco Presta
Dec 3, 2008·Cancer Research·A Francesca SetiadiWilfred A Jefferies
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary L Disis
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 23, 2011·Chinese Medicine·Wen TanYitao Wang
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Oct 23, 2012·Chinese Journal of Integrative Medicine·Bin WangTian Xie
Dec 12, 2012·Cancer Research·Katarzyna FranciszkiewiczFathia Mami-Chouaib
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Klinger Antonio da Franca RodriguesFernando Aécio de Amorim Carvalho
Aug 31, 2013·Cancer Letters·Yongzhong WuJames H Doroshow
Jan 3, 2014·Oxidative Medicine and Cellular Longevity·Shiho OhnishiShosuke Kawanishi
Jan 5, 2014·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Yuqiu MaoXiaonan Cui
Jan 15, 2014·Seminars in Cancer Biology·Eliane CortezKristian Pietras
Jun 15, 2014·Bioorganic & Medicinal Chemistry Letters·Jichao ChenJinyi Xu
Oct 3, 2014·Journal of Natural Products·Guo-Ping YinZheng-Tao Wang
Nov 8, 2014·Annals of the Rheumatic Diseases·Stephanie M StanfordNunzio Bottini
Jan 7, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jun ZhangJin Hai Tang
Jun 16, 2015·Chinese Journal of Natural Medicines·Ying ZhongJing Shang
Aug 5, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kristen Fousek, Nabil Ahmed

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Citations

Apr 28, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rama Rao MallaVenkata Ramesh Dasari
Jun 3, 2020·European Journal of Pharmacology·Milad AshrafizadehMasoud Najafi

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BETA
nuclear translocation

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