PMID: 2626038Jan 1, 1989Paper

The antitumor mechanism of progesterone antagonists is a receptor mediated antiproliferative effect by induction of terminal cell death

Journal of Steroid Biochemistry
H MichnaM F El Etreby

Abstract

The antiprogesterones Onapristone, ZK 112.993 (Schering AG), and Mifepristone (Roussel-Uclaf) proved to possess progesterone receptor-mediated antiproliferative effects in experimental mammary carcinomas. In this study, the potency and mechanism of the antitumor action of Onapristone and ZK 112.993 is characterized by ovariectomized, progestagen and/or estradiol substituted mice bearing hormone-dependent MXT(+) mammary tumours. Medroxyprogesterone acetate (MPA, 0.8 mg/mouse, 3 times weekly, s.c.) could only induce a poor stimulation of tumour growth (% T/C = 40; intact control % T/C = 100), which was only marginally inhibited (% T/C = 21) by Onapristone (0.2 mg/mouse, 6 times weekly, s.c.) during a 6-week therapy. Therefore, the antitumor mechanism of antiprogesterones cannot preferably depend on a classical progesterone antagonism. In contrary, the pronounced stimulation of tumor growth (% T/C = 152) by estradiol benzoate (EB, 0.33 microgram/mouse, 3 times weekly, s.c.) was completely inhibited (% T/C = 7) by the antiprogesterones. An even more stimulated tumour growth was achieved by a combination of EB and MPA (% T/C = 365 using 0.17 mg; % T/C = 225 using 0.8 mg MPA). Onapristone dramatically blocked tumor growth (% T/C = 7)...Continue Reading

Citations

May 1, 1993·Clinical & Experimental Metastasis·Y E ShiE W Thompson
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·P HilgardJ Engel
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·K Parczyk, M R Schneider
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·M R SchneiderK Pollow
Dec 1, 1990·Breast Cancer Research and Treatment·H MichnaW L McGuire
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·M R SchneiderM F el Etreby
Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM F el Etreby
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM R Schneider
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM R Schneider
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·Y NishinoM R Schneider
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·P H JellinckC R Lyttle
Apr 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·G VollmerR Knuppen
Apr 24, 1999·The Journal of Steroid Biochemistry and Molecular Biology·M F MontecchiaC Lanari
Apr 1, 1997·Critical Reviews in Oncology/hematology·G Vollmer
Jan 8, 1999·Breast Cancer Research and Treatment·M F El EtrebyP V Schoenlein
Aug 8, 1998·Breast Cancer Research and Treatment·M F El Etreby, Y Liang
Jun 12, 1995·Annals of the New York Academy of Sciences·H MichnaY Nishino
Apr 28, 2006·Bioorganicheskaia khimiia·L E GolubovskaiaV M Rzheznikov
Apr 1, 1993·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·E RumpelW Kühnel
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D L Manning, R I Nicholson
Jan 1, 1996·Acta Oncologica·K B HorwitzG S Takimoto
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Dowsett
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·J H CheckJ Szekeres-Bartho
Apr 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C DanneckerS Classen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.