The antiviral alkaloid berberine ameliorates neuropathic pain in rats with peripheral nerve injury.

Acta neurologica Belgica
Shaomin YangYue Hao

Abstract

Neuropathic pain is a major public health problem. There is a need to develop safer and more effective analgesia compounds with less side effects. Berberine has been used to treat diarrhea and gastroenteritis due to its anti-microbial, anti-motility and anti-secretory properties. Berberine has also been reported to play an analgesic role in some pathological conditions of pain. However, the analgesic roles of berberine in neuropathic pain are still unclear. Therefore, this study aims to explore the analgesic effects of berberine in neuropathic pain. Partial sciatic nerve ligation (pSNL) was performed to create neuropathic pain model. Paw withdrawal responses to mechanical and thermal stimuli were measured using a set of electronic von Frey apparatus and hot plate, respectively. The time that rats spent licking, flinching and lifting its paw during 5 min following capsaicin application was recorded. mRNA and protein expression levels were examined by quantitative RT-PCR and western blot, respectively. Berberine administration (i.p.) increased both mechanical and thermal pain thresholds in a dose-dependent manner. Moreover, berberine administration reversed the mRNA and protein expression of TRPV1 in dorsal root ganglion neurons ...Continue Reading

References

Apr 3, 2001·Annual Review of Neuroscience·M J Caterina, D Julius
Sep 14, 2004·Journal of Neurobiology·Makoto Tominaga, Michael J Caterina
Mar 18, 2006·European Journal of Pain : EJP·James E BiggsPeter P Robinson
Jan 30, 2008·The Journal of Pain : Official Journal of the American Pain Society·Hyun Yeong KimSeog Bae Oh
Mar 17, 2010·Mayo Clinic Proceedings·Robert H DworkinChristopher D Wells
Jul 24, 2010·Lancet Neurology·Ralf BaronGunnar Wasner
Oct 16, 2010·Nature Medicine·Rohini Kuner
Jul 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sacha MalinBrian M Davis
Sep 21, 2011·International Journal of Nanomedicine·Wen TanYitao Wang
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erica S SchwartzG F Gebhart
Jun 6, 2013·Journal of Medicinal Food·Si Oh Kim, Hyun Jee Kim
May 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Qian LiYan-Qing Wang
Feb 18, 2016·EMBO Reports·Wuping SunMakoto Tominaga
Nov 5, 2016·Science·Ru-Rong JiYu-Qiu Zhang
May 11, 2017·Nature Communications·Maria Cristina MarroneSilvia Marinelli
Aug 2, 2018·Frontiers in Molecular Neuroscience·Wuping SunChangyu Jiang

❮ Previous
Next ❯

Citations

Jul 31, 2020·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Oct 10, 2020·Drug Delivery and Translational Research·Majid RahmatiMajid Salehi
Dec 20, 2020·Phytotherapy Research : PTR·Mahmoud Hashemzaei, Ramin Rezaee

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
PCR

Software Mentioned

Origin
- 7500
ABI

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.