The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

Journal of Traditional and Complementary Medicine
Andréa D Fuzimoto, Ciro Isidoro

Abstract

As of March 11th, 2020, the World Health Organization declared the COVID-19 outbreak a pandemic. Articles published after the SARS-CoV-1 (2002) epidemic suggest that the use of an herbal-drug integrative medical approach could have contributed to a lower fatality rate and a more rapid response in controlling the outbreak. Pubmed was searched for articles that investigated the antiviral properties and mechanisms of action of herbs or natural compounds against the SARS-coronavirus (CoV). Forty-three (43) relevant papers were located. A general count rendered 450+ herbs and natural compounds with antiviral properties against the SARS-CoV and related viruses. From the 43 articles, thirty-one (31) uncovered the mechanisms of action of the natural substances able to oppose the coronavirus. A series of herbs and natural compounds demonstrated moderate to strong antiviral activity. Research on many herbs-natural compounds also showed potent and significant inhibition of CoV-host protein pathways responsible for different phases of viral replication specifically targeting 3CLPRO, PLPRO, RdRp, helicase protein, S protein, N protein, 3a protein, Cathepsin L, Nsp1, Nsp3c, and ORF7a, and the S protein/ACE-2 interaction. The herbs-natural co...Continue Reading

Citations

Aug 28, 2020·Frontiers in Pharmacology·Bachir Benarba, Atanasio Pandiella
Aug 28, 2020·Frontiers in Medicine·Farhana Rumzum BhuiyanMahmudul Hasan
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Burtram C FieldingDamião Pergentino de Sousa
Feb 2, 2021·Journal of Traditional and Complementary Medicine·Panthakarn RangsinthSiriporn Chuchawankul
Feb 2, 2021·Journal of Traditional and Complementary Medicine·Anchalee PrasansuklabTewin Tencomnao
Feb 16, 2021·Network Modeling and Analysis in Health Informatics and Bioinformatics·Sapan ShahGovind Lohiya
Jan 6, 2021·Vaccines·Nasir MahmoodKathleen Hefferon
Feb 5, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mohamed A SaidHany S Ibrahim
Mar 16, 2021·Journal of Biomolecular Structure & Dynamics·Debanjan SenSudhan Debnath
Apr 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Douglas DouradoE Sócrates T Egito
May 25, 2021·Journal of Traditional and Complementary Medicine·Ahmed A ZakiAhmed A Al-Karmalawy
Jun 9, 2021·Journal of Traditional and Complementary Medicine·Rahul SinghSanjay Kumar
Aug 3, 2021·Frontiers in Pharmacology·Ghazaleh MoslehAbdolali Mohagheghzadeh
Sep 8, 2021·Environmental Science and Pollution Research International·Rajeshwari SinghDevesh Tewari

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Methods Mentioned

BETA
deubiquitination

Software Mentioned

3CL

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