The anx/anx Mouse - A Valuable Resource in Anorexia Nervosa Research

Frontiers in Neuroscience
Ida Nilsson

Abstract

Animal models are invaluable resources in research concerning the neurobiology of anorexia nervosa (AN), to a large extent since valid clinical samples are rare. None of the existing models can capture all aspects of AN but they are able to mirror the core features of the disorder e.g., elective starvation, emaciation and premature death. The anorectic anx/anx mouse is of particular value for the understanding of the abnormal response to negative energy balance seen in AN. These mice appear normal at birth but gradually develops starvation and emaciation despite full access to food, and die prematurely around three weeks of age. Several changes in hypothalamic neuropeptidergic and -transmitter systems involved in regulating food intake and metabolism have been documented in the anx/anx mouse. These changes are accompanied by signs of inflammation and degeneration in the same hypothalamic regions; including activation of microglia cells and expression of major histocompatibility complex I by microglia and selective neuronal populations. These aberrances are likely related to the dysfunction of complex I (CI) in the oxidative phosphorylation system of the mitochondria, and subsequent increased oxidative stress, which also has bee...Continue Reading

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Citations

Apr 11, 2020·The International Journal of Eating Disorders·Claudio D'AddarioPaola Fadda
Jan 31, 2020·Frontiers in Nutrition·Mathieu MéquinionZane B Andrews
Jan 7, 2021·International Journal of Molecular Sciences·Mariangela PucciClaudio D'Addario
Jul 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Claire J FoldiBrian J Oldfield

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