The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats

Scientific Reports
Jia-Ning XuDong Shen

Abstract

The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). The anxiolytic-like activities were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced by blocking the decreased time and entries in the open arms in elevated plus maze test and by reversing the increased latency to feed in novelty-suppressed feeding test. In addition, the decreased levels on progesterone, allopregnanolone, serotonin (5-HT) in the prefrontal cortex and hippocampus of chronic unpredictable stress (CUS) were blocked by GRg3 (20 and 40 mg/kg, i.g). Furthermore, the increased corticotropin releasing hormone, corticosterone and adrenocorticotropic hormone were blocked by GRg3 (20 and 40 mg/kg, i.g). Collectively, the anxiolytic-like effects produced by GRg3 were associated with the normalization of neurosteroids biosynthesis, serotonergic system as well as HPA axis dysfunction.

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Citations

May 28, 2020·Frontiers in Pharmacology·Chan LiYuan-Wei Zhang
Dec 29, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yan-Ling QiaoXiao-Chi Ma
May 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shiyi ChenYiping Ye

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
ELISA

Software Mentioned

GraphPad Prism

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