The Anyang Esophageal Cancer Cohort Study: study design, implementation of fieldwork, and use of computer-aided survey system.

PloS One
Fangfang LiuYang Ke

Abstract

Human papillomavirus (HPV) has been observed repeatedly in esophageal squamous cell carcinoma (ESCC) tissues. However, the causal relationship between HPV infection and the onset of ESCC remains unknown. A large cohort study focusing on this topic is being carried out in rural Anyang, China. The Anyang Esophageal Cancer Cohort Study (AECCS) is a population-based prospective endoscopic cohort study designed to investigate the association of HPV infection and ESCC. This paper provides information regarding the design and implementation of this study. In particular we describe the recruitment strategies and quality control procedures which have been put into place, and the custom designed computer-aided survey system (CASS) used for this project. This system integrates barcode technology and unique identification numbers, and has been developed to facilitate real-time data management throughout the workflow using a wireless local area network. A total of 8,112 (75.3%) of invited subjects participated in the baseline endoscopic examination; of those invited two years later to take part in the first cycle of follow-up, 91.9% have complied. The AECCS study has high potential for evaluating the causal relationship between HPV infectio...Continue Reading

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Citations

Jan 24, 2016·Chinese Journal of Cancer·Ying ShiYa Cao
Sep 28, 2016·World Journal of Gastroenterology : WJG·Dania BucchiGiuseppe Masanotti
Jun 6, 2013·Emerging Infectious Diseases·Zhonghu HeYang Ke
Jul 19, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dong HangYang Ke
Sep 14, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mengfei LiuYang Ke

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Methods Mentioned

BETA
biopsy
enzyme-linked
scraping
biopsies
blood drawn
hysterectomies

Software Mentioned

AECCS
CASS
Structured Query Language ( SQL ) Server
PASS

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