The APC-EB1 interaction

Advances in Experimental Medicine and Biology
Ewan E Morrison

Abstract

Changes in cell proliferation seen in cancers initiated by adenomatous polyposis coli (APC) gene mutation are driven by the loss of an ability to negatively regulate the canonical WNT signalling pathway. However, mutant APC proteins also lack the ability to interact with a number of other ligands and it is possible that the loss of these interactions could contribute to the phenotype or to the development ofcolorectal tumours. One such association is with the microtubule plus-end binding protein EB1. Originally identified as an APC binding partner, EB1 is now known to be part of an evolutionarily conserved family of proteins involved in the regulation of microtubule dynamics and microtubule-dependent processes. Roles for the interaction between APC and EB1 have been identified in cellular functions as diverse as directed cell migration and mitosis, with potentially important implications for the behaviour of both normal epithelial cells and colorectal cancer cells. In this chapter our current understanding of the functional role of the APC-EB1 interaction will be reviewed.

Citations

Dec 15, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takumi MatsumotoSakae Tanaka
Feb 19, 2015·International Journal of Molecular Sciences·Cheng-Yi ChenKwang-Huei Lin
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kit-Ying ChungNathalie Wong
Jun 5, 2015·The FEBS Journal·Yael Maizels, Gabi Gerlitz
Mar 2, 2017·International Journal of Molecular Sciences·Chon-Kit ChouChien-Chih Chiu
Nov 6, 2018·Tissue Barriers·Ekaterina Vasileva, Sandra Citi
Oct 14, 2019·Breast Cancer Research and Treatment·Sylvie Rodrigues-FerreiraClara Nahmias
Jul 7, 2011·The Journal of Biological Chemistry·Andrea Pelikan-ConchaudronMarie-France Carlier
Oct 3, 2020·Current Biology : CB·Maria Angeles JuanesBruce L Goode

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.