The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study

Neurobiology of Aging
Phillip J TullyChristophe Tzourio

Abstract

The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.

References

Oct 4, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Yung-Chieh YenChun-Hua Shih
Jan 13, 2009·Journal of Psychiatric Research·Paul G SurteesSheila A Bingham
Jan 10, 2012·Journal of Affective Disorders·R SureshkumarM Varghese
Jun 16, 2012·International Journal of Geriatric Psychiatry·Mayumi NoseTakashi Asada

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Citations

Feb 18, 2020·Current Alzheimer Research·Agnieszka BrzezińskaJakub Kaźmierski
Mar 3, 2021·Psychological Medicine·Matthew H IvesonAndrew M McIntosh
May 20, 2021·International Journal of Geriatric Psychiatry·Inbar LavieRamit Ravona-Springer

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