The apolipoprotein E epsilon 4 allele is not associated with early onset temporal lobe epilepsy

Neuroreport
I BlümckeO D Wiestler

Abstract

A polymorphism of the apolipoprotein E gene, in particular the epsilon 4 allele (ApoE4), has been associated with impaired neuronal phospholipid metabolism and synapse reorganization and has been implicated in several neurodegenerative disorders. Since selective neuronal cell lose and aberrant axonal reorganization represent hall-marks of Ammon's horn sclerosis (AHS) in patients with chronic temporal lobe epilepsy (TLE), the ApoE polymorphism was studied in 125 patients with TLE. The genotype analysis revealed a frequency of 15.5% for epsilon 4, and 74.8% and 9.8% for epsilon 3 and epsilon 2, respectively. These figures were not significantly different from those reported in the normal European population. In addition, no correlation was found between the ApoE4 allelotype and the age of epilepsy onset, seizure type, febrile seizures, family history of epilepsy, surgical outcome and neuropathological findings in patients with TLE. These data virtually exclude ApoE as a susceptibility gene involved in the pathogenesis of early onset TLE or AHS.

References

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Citations

Dec 11, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Annick SalzmannAlain Malafosse
Dec 20, 2005·Epilepsia·Sanjay M Sisodiya
Oct 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M C Dalakas
Aug 4, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pierre LavenexTyphaine Juvet
Sep 23, 2008·Pediatric Neurology·Ozlem GirayDerya Erçal
Sep 9, 2006·Journal of Psychiatric Research·Julia WilhelmStefan Bleich
Jul 30, 2009·Acta Oncologica·Shala Ghaderi BerntssonAnja Smits
Oct 29, 2004·Epilepsia·Nigel C K TanSamuel F Berkovic
Oct 22, 2010·Brain Injury : [BI]·Megan A MillerAmy K Wagner
Jul 24, 2010·Neurologia i neurochirurgia polska·Krystyna Pierzchala
May 13, 2005·Brain : a Journal of Neurology·Gianpiero L CavalleriDavid B Goldstein
Feb 1, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S N YeniM Uzan

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