PMID: 9184645Jun 1, 1997Paper

The apoptotic death of neuroblastoma cells caused by serum from patients with insulin-dependent diabetes and neuropathy may be Fas-mediated

Journal of Neuroimmunology
G L PittengerA I Vinik

Abstract

Immunoglobulins from patients with diabetic neuropathy are toxic to neuroblastoma cells. The cell death has characteristics of apoptosis: condensed chromatin, shrunken cytoplasm, elevation of [Ca2+]i and DNA fragmentation. N1E-115 cell membranes contain Fas, a regulator of apoptosis that recently has been shown to be involved in pancreatic beta-cell destruction leading to diabetes. Fas-specific antibodies bind to the surface of N1E-115 cells and induce apoptosis. Serum from patients with diabetic neuropathy block Fas-antibody binding. We conclude that sera from patients with diabetic neuropathy contain an activator of Fas-regulated apoptosis that may contribute to the pathogenesis of diabetic neuropathy.

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Citations

Sep 14, 1999·The American Journal of Medicine·A I Vinik
Jan 8, 2000·Journal of Neuroimmunology·J Knezevic-CucaG L Pittenger
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Mar 10, 2005·The Kaohsiung Journal of Medical Sciences·Chun-Chiang HuangMao-Hsiung Huang
Sep 20, 2015·Immunology Letters·Noor M JanahiMairghread Ellis
Jul 27, 2005·Diabetes Care·Aaron I VinikJagdeesh Ullal
May 31, 2014·The Journal of International Medical Research·Fawzia Al RouqSultan Ayoub Meo
Dec 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Fei LiMartin J Stevens
Dec 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Shao-Nian Yang, Per-Olof Berggren
Feb 28, 2008·Neuroreport·Roberto TownsJohn W Wiley
Jul 27, 2006·Endocrine Reviews·Shao-Nian Yang, Per-Olof Berggren
Sep 24, 1998·Journal of Neurophysiology·H RisticJ W Wiley
Sep 27, 2007·Experimental Biology and Medicine·Marlyn P LangfordRobert McVie
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hélène Bour-JordanJeffrey A Bluestone

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