The apparent inhibition of superoxide dismutase activity by quinones

Journal of Free Radicals in Biology & Medicine
J Butler, B Hoey

Abstract

It has been demonstrated that several quinones can modify the activity of bovine copper superoxide dismutase by undergoing equilibrium reactions with superoxide radicals. The extent of this apparent inhibition correlates with the one electron reduction potentials of the quinones and the equilibrium constants of the semiquinone radical/superoxide radical reactions. Various rate constants have been estimated including those for the reactions of semiquinone radicals with cytochrome c and with superoxide dismutase. Semiquinone radicals cannot be dismutated by superoxide dismutase.

References

Sep 1, 1979·Archives of Biochemistry and Biophysics·H M Hassan, I Fridovich
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·C C WinterbournB Halliwell
Oct 1, 1984·Biochemical Pharmacology·M T Smith, C G Evans
Jun 1, 1981·Archives of Biochemistry and Biophysics·C C Winterbourn
Aug 1, 1983·Archives of Biochemistry and Biophysics·E J LandJ M Bruce
Jun 1, 1982·Journal of Medicinal Chemistry·I AntoniniA C Sartorelli
Jun 1, 1962·The Biochemical Journal·D H BISHOPH K KING

❮ Previous
Next ❯

Citations

Jan 1, 1989·Free Radical Biology & Medicine·A Brunmark, E Cadenas
Oct 1, 1992·Free Radical Biology & Medicine·A BindoliD J Deeble
Feb 1, 1995·Free Radical Biology & Medicine·Y KumagaiM Sagai
Apr 7, 1998·Chemico-biological Interactions·R MundayC M Munday
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A VanellaJ R Perez-Polo
May 1, 1995·Free Radical Biology & Medicine·M S Paller, J W Eaton
Jan 1, 1988·Free Radical Biology & Medicine·P Bellavite
Jan 1, 1990·Chemico-biological Interactions·K OllingerE Cadenas
Apr 1, 2014·Free Radical Biology & Medicine·Xiu YuanT David Waite
Nov 4, 2017·Marine Drugs·Concetta ImperatoreAntonio Doménech-Carbó
Nov 25, 2003·The American Journal of Forensic Medicine and Pathology·M Sunay YavuzMuzaffer Altinkok
Jan 1, 1990·Free Radical Research Communications·J ButlerB M Hoey
Jan 1, 1994·International Journal of Radiation Biology·P WardmanM Tracy
Jan 1, 1990·Free Radical Research Communications·P Wardman
Sep 22, 1999·Chemical Research in Toxicology·R C LawsonA E Alegría
Mar 6, 2008·Journal of Medicinal Chemistry·Sanjeev KumarAlexander J Muller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.