PMID: 2487081Jan 1, 1989Paper

The appearance and distribution of microglia in the developing retina of the rat

Visual Neuroscience
K W AshwellJ Stone

Abstract

We have examined the development of microglia in the rat retina, using a peroxidase-conjugated lectin derived from Griffonia simplicifolia. Retinas were studied from animals aged from E(embryonic day)12, just after the invagination of the optic cup and prior to the closure of the optic fissure, to adulthood. The lectin also proved a sensitive label for the endothelial cells of the developing retina. Our results provide some support for the view that microglia are derived from the monocyte-macrophage series of blood cells. At E12, most labeled cells were found at the vitreal surface, suggesting that they had come from the hyaloid circulation, while some had entered the retina and appeared to be migrating towards its ventricular surface. From E14 to early postnatal ages, most labeled cells had processes and resembled the amoeboid microglial cells described in silver carbonate staining studies (Ling, 1982). The number of labeled cells rose from about 700 to E14 to a peak of about 27,000 at P(postnatal day)7, and fell to about 19,600 by P12. As early as E16, a regularity was apparent in the distribution of microglial cells over the surface of the retina, the cells tending to avoid each other. Microglial cells are found throughout t...Continue Reading

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Citations

Jan 1, 1992·Brain Research. Brain Research Reviews·W E Thomas
Sep 1, 1990·Brain Research. Developmental Brain Research·K Ashwell
Jan 15, 1991·Brain Research. Developmental Brain Research·K Ashwell
Nov 22, 1996·Brain Research. Developmental Brain Research·R EgenspergerJ Stone
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Aug 10, 2000·Anais Da Academia Brasileira De Ciências·J NavascuésM A Cuadros
Mar 4, 2000·The Journal of Comparative Neurology·M Salvador-SilvaM P Villegas-Pérez

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