PMID: 3320162Dec 1, 1987Paper

The appearance of macrophage migration-inhibition factor in drug reactions

The Journal of Allergy and Clinical Immunology
E LivniH Joshua

Abstract

Drug-induced adverse reactions were suspected in 2030 patients with known exposure to 243 different drugs. A modified direct macrophage migration-inhibition factor (MIF) test for the different drugs was carried out on blood samples from these patients. There was a positive MIF response toward one or more of the suspected drugs in 53.4% of the patients as compared to 4.9% of the control group; 155 of the 243 drugs elicited a positive MIF response. The percentage of positive responses for each particular drug was not related to the number of patients tested, reflecting the variability in specific immunogenicity of the different drugs. The high percentage of positive MIF reactions in relation to the clinical diagnosis suggests that this test can be a useful aid in the detection of the offending drug in cases of suspected drug-induced reactions.

Citations

Dec 30, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B AmichaiS Halevy
Jun 27, 1998·Clinics in Dermatology·S BrennerV Ruocco
May 8, 1999·Clinical and Experimental Dermatology·B Amichai, M H Grunwald
Jul 6, 2000·Journal of the European Academy of Dermatology and Venereology : JEADV·M LandauS Brenner
Feb 1, 1991·International Journal of Dermatology·S Kivity
Jul 1, 1993·International Journal of Dermatology·G SacerdotiV Ruocco
Jul 1, 1993·International Journal of Dermatology·R WolfS Brenner
Aug 1, 1993·Journal of the American Academy of Dermatology·S HalevyE Livni
Sep 1, 1993·Journal of the American Academy of Dermatology·S Halevy, E Livni
May 9, 2012·Epilepsy & Behavior : E&B·S HajnsekD Stulhofer Buzina
Oct 1, 1990·International Journal of Dermatology·M H GrunwaldS Halevy
Feb 26, 2004·The Annals of Pharmacotherapy·Roberta L ColtonAvraham Zeharia
Mar 1, 1991·International Journal of Dermatology·R WolfS Brenner
May 1, 1996·The Annals of Pharmacotherapy·L HarelI Varsano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Journal of the American Academy of Dermatology
S Brenner, E Livni
Contact Dermatitis
C RomagueraA Azon
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
B Nyfeler, W J Pichler
© 2021 Meta ULC. All rights reserved