The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1-70 kd and B'/B proteins as predominant U1 RNP immunogens

Arthritis and Rheumatism
Eric L Greidinger, R W Hoffman

Abstract

To observe the order of development of anti-U1 RNP peptide antibodies in humans. Immunoblots against Jurkat cell lysates were performed on 5,882 serum samples from 3,668 patients referred on clinical grounds for RNP antibody testing to a reference laboratory between 1989 and 1999. In patients from whom multiple samples were drawn, we determined the order in which IgG antibodies to the U1 RNP peptides A, B'/B, C, D, and 70 kd appeared. One hundred sixty-three patients with serial samples were identified in whom antibodies to at least one U1 RNP peptide initially were not present but later appeared. The first RNP antibodies to appear were most often directed against the 70 kd and B'/B peptides (P < 0.01). Antibodies to the A and C peptides usually developed after other RNP peptide antibodies, and antibodies to D often emerged only after immunity to multiple other U1 RNP proteins had appeared. B'/B, but not 70 kd, was a frequent early target of spreading after initial immunity to other RNP peptides. Orderly patterns of emergence of U1 RNP peptide antibodies appear to exist in humans. Two peptides, 70 kd and B'/B, show characteristics of early immunogens in the development of human RNP immunity.

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Citations

Jul 13, 2002·Arthritis and Rheumatism·Eric L GreidingerRobert W Hoffman
Jul 13, 2002·Arthritis and Rheumatism·Fanny Monneaux, Sylviane Muller
Aug 16, 2008·Immunologic Research·Barbara J Vilen, Jennifer A Rutan
Mar 13, 2010·PloS One·Latisha D HeinlenJohn B Harley
Apr 14, 2011·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hani A Al-ShobailiZafar Rasheed
Aug 28, 2014·Modern Rheumatology·Agnieszka Paradowska-GoryckaMarzena Olesinska
Aug 3, 2006·Scandinavian Journal of Rheumatology·S BaráthE Bodolay
Sep 4, 2015·Autoimmunity·David James HaddonPaul J Utz
Jan 25, 2003·The Journal of Investigative Dermatology·Yoshihide AsanoKunihiko Tamaki
Feb 19, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Yuka OkuraIchiro Kobayashi
Jan 31, 2009·Arthritis and Rheumatism·Eric L GreidingerRobert W Hoffman
Feb 28, 2009·Arthritis and Rheumatism·Brian D PooleJudith A James
Aug 13, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Umesh S DeshmukhShu Man Fu
Jul 26, 2002·Lupus·G C Sharp
Oct 1, 2004·Arthritis and Rheumatism·Robert W HoffmanEric L Greidinger
Feb 3, 2006·Arthritis and Rheumatism·Eric L GreidingerRobert W Hoffman
Aug 1, 2008·Clinical and Vaccine Immunology : CVI·Matthias MajetschakRobert W Hoffman
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Umesh S DeshmukhShu Man Fu
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric L GreidingerRobert W Hoffman
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mihiri De Silva-UdawattaRobert W Hoffman
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric L GreidingerRobert W Hoffman
Jan 4, 2016·Antibodies·Barbara Dema, Nicolas Charles
Mar 17, 2021·Trends in Molecular Medicine·Sandra G Williams, Sandra L Wolin
May 26, 2021·Journal of Autoimmunity·Masaru TakeshitaTsutomu Takeuchi
Apr 29, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Robert W Hoffman, Marcos E Maldonado

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