The Application and Interpretation of IgG Avidity and IgA ELISA Tests to Characterize Zika Virus Infections

Viruses
Fátima AmaroFernando De Ory

Abstract

In the absence of viremia, the diagnostics of Zika virus (ZIKV) infections must rely on serological techniques. In order to improve the serological diagnosis of ZIKV, ZIKV-IgA and ZIKV-IgG avidity assays were evaluated. Forty patients returning from ZIKV endemic areas, with confirmed or suspected ZIKV infections were studied. Samples were classified as early acute, acute and late acute according to the number of days post illness onset. Low avidity IgG was only detected at acute and late acute stages and IgA mostly at the early acute and acute stages. The date of sampling provides useful information and can help to choose the best technique to use at a determined moment in time and to interpret low avidity IgG and IgA results, improving the serological diagnosis of ZIKV.

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Citations

Mar 17, 2019·Viruses·Luis Martinez-Sobrido, Fernando Almazán
Feb 9, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Elise BouthryChristelle Vauloup-Fellous
Sep 18, 2021·Expert Review of Vaccines·D Herbert OpiJames G Beeson

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Methods Mentioned

BETA
ELISA
PCR

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