The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder cancer progression.

European Urology
James W F CattoFreddie C Hamdy

Abstract

New methods for identifying bladder cancer (BCa) progression are required. Gene expression microarrays can reveal insights into disease biology and identify novel biomarkers. However, these experiments produce large datasets that are difficult to interpret. To develop a novel method of microarray analysis combining two forms of artificial intelligence (AI): neurofuzzy modelling (NFM) and artificial neural networks (ANN) and validate it in a BCa cohort. We used AI and statistical analyses to identify progression-related genes in a microarray dataset (n=66 tumours, n=2800 genes). The AI-selected genes were then investigated in a second cohort (n=262 tumours) using immunohistochemistry. We compared the accuracy of AI and statistical approaches to identify tumour progression. AI identified 11 progression-associated genes (odds ratio [OR]: 0.70; 95% confidence interval [CI], 0.56-0.87; p=0.0004), and these were more discriminate than genes chosen using statistical analyses (OR: 1.24; 95% CI, 0.96-1.60; p=0.09). The expression of six AI-selected genes (LIG3, FAS, KRT18, ICAM1, DSG2, and BRCA2) was determined using commercial antibodies and successfully identified tumour progression (concordance index: 0.66; log-rank test: p=0.01). AI...Continue Reading

References

Jan 1, 1990·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·E A ReedyJ H Resau
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·M P BrownD Haussler
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·James W F CattoFreddie C Hamdy
Apr 2, 2004·Nature Reviews. Cancer·David F Ransohoff
Dec 8, 2004·Lancet·Freddie C Hamdy, James W F Catto
May 21, 2005·Bioinformatics·Annette M MolinaroRuth M Pfeiffer
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter J WildArndt Hartmann
Jul 20, 2005·Artificial Intelligence in Medicine·Te Ming Huang, Vojislav Kecman
Oct 26, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Martin G FriedrichGangning Liang
Jan 13, 2006·The Journal of Urology·James W F CattoFreddie C Hamdy
Jan 18, 2007·Journal of the National Cancer Institute·Alain Dupuy, Richard M Simon
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lars DyrskjøtTorben F Orntoft
Aug 19, 2007·The Journal of Urology·Maysam F AbbodFreddie C Hamdy
Feb 5, 2008·IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society·M Y Chen, D A Linkens
Apr 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James W F CattoFreddie C Hamdy

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Citations

Oct 21, 2010·Der Urologe. Ausg. A·C Protzel, O W Hakenberg
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Markus RiesterFranziska Michor
Feb 23, 2011·Der Urologe. Ausg. A·M Burger, F Vom Dorp
Oct 26, 2014·Journal of the National Cancer Institute·Anirban P MitraPeter C Black
Feb 8, 2011·European Urology·James W F CattoTapio Visakorpi
May 7, 2014·Pathology·Nikhil SapreChristopher M Hovens
Aug 22, 2014·Cancer Medicine·Edyta M BorkowskaBogdan Kaluzewski
Feb 13, 2019·Carcinogenesis·H Lalremmawia, Basant K Tiwary
May 31, 2012·British Journal of Cancer·S MiahJ W F Catto
Dec 14, 2019·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Enrico CheccucciUNKNOWN Uro-technology and SoMe Working Group of the Young Academic Urologists Working Party of the European Association of Urology
Jul 26, 2016·Biomedical Reports·Lin-Feng Zheng, Wen-Yong Sun
Jun 3, 2015·Molecular Cancer Research : MCR·Chao ChengCarmen J Marsit
Aug 14, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Se-Ra LeeSun-Hee Leem
Jul 24, 2021·BMC Medical Informatics and Decision Making·Hesham SalemAmir Awwad

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