The Application of Brain Organoids: From Neuronal Development to Neurological Diseases

Frontiers in Cell and Developmental Biology
Yikai ShouXuekun Li

Abstract

Brain organoids are derived from induced pluripotent stem cells and embryonic stem cells under three-dimensional culture condition. The generation of an organoid requires the self-assembly of stem cells, progenitor cells, and multiple types of differentiated cells. Organoids display structures that resemble defined brain regions and simulate specific changes of neurological disorders; thus, organoids have become an excellent model for investigating brain development and neurological diseases. In the present review, we have summarized recent advances of the methods of culturing brain organoids and the applications of brain organoids in investigating neurodevelopmental and neurodegenerative diseases.

References

Nov 6, 1998·Science·J A ThomsonJ M Jones
Jul 1, 2008·Parkinsonism & Related Disorders·Marie-Francoise ChesseletBernd Meurers
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan RutkowskiJacques Grill
Jul 26, 2013·Brain : a Journal of Neurology·Jeffrey H KordowerRaymond T Bartus
Sep 3, 2013·Nature·Madeline A LancasterJuergen A Knoblich
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Taisuke KadoshimaYoshiki Sasai
Jul 19, 2014·Science·Madeline A Lancaster, Juergen A Knoblich
Sep 5, 2014·Nature Protocols·Madeline A Lancaster, Juergen A Knoblich
Jun 13, 2015·Nature Protocols·Young Hye KimDoo Yeon Kim
Aug 6, 2015·Nature Reviews. Neuroscience·Frances K WisemanAndré Strydom
Jan 11, 2016·Cell Stem Cell·Xiaolei YinOren Levy
Jan 15, 2016·Nature Communications·Chikafumi OzoneYoshiki Sasai
Mar 2, 2016·The EMBO Journal·Elke GabrielJay Gopalakrishnan
Mar 31, 2016·The New England Journal of Medicine·Rita W DriggersOlli Vapalahti
Apr 12, 2016·Science·Patricia P GarcezStevens K Rehen
Jul 13, 2016·Developmental Biology·Iva Kelava, Madeline A Lancaster
Sep 28, 2016·Developmental Cell·Kai Kretzschmar, Hans Clevers
Mar 12, 2017·The EMBO Journal·Magdalena RennerJuergen A Knoblich
Apr 19, 2017·Stem Cell Reports·Anna S MonzelJens C Schwamborn
Apr 27, 2017·Nature·Giorgia QuadratoPaola Arlotta
Jul 29, 2017·Lab on a Chip·Yujuan ZhuJianhua Qin
Sep 8, 2017·Nature Reviews. Neuroscience·Elizabeth Di Lullo, Arnold R Kriegstein
Dec 12, 2017·Current Opinion in Cell Biology·Giorgia Quadrato, Paola Arlotta
Feb 14, 2018·Lab on a Chip·Yaqing WangJianhua Qin
Apr 13, 2018·Translational Psychiatry·Priya SrikanthTracy L Young-Pearse
May 16, 2018·Nature Physics·Eyal KarzbrunOrly Reiner
Jul 15, 2018·Current Opinion in Cell Biology·Michael HeideFelipe Mora-Bermúdez
Jul 27, 2018·Nature Methods·Mayur MadhavanPaul J Tesar

❮ Previous
Next ❯

Citations

Jan 1, 2021·Neurobiology of Disease·Abraham Andreu-CerveraSylvie Schneider-Maunoury
Mar 5, 2021·Frontiers in Cell and Developmental Biology·Lucía Florencia Franchini
May 5, 2021·Developmental Neurobiology·Foluwasomi A OyefesoMichael J Pecaut
May 27, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jing-Han NgEng-King Tan
Jul 15, 2021·ACS Chemical Neuroscience·Olga Y AntonovaYuri M Shlyapnikov
Aug 26, 2021·Chembiochem : a European Journal of Chemical Biology·Lea S van HusenSimon J Elsässer

❮ Previous
Next ❯

Methods Mentioned

BETA
chips
single-cell sequencing
MDS
scRNA-seq

Related Concepts

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Brain Organoids in Disease Modeling

Brain organoids are three-dimensional cell culture models derived from human pluripotent stem cells. Since they resemble the embryonic brain, they can be used to help study brain biology, early brain development, and brain diseases. Discover the latest research on brain organoids in disease modeling here.

Related Papers

Current Opinion in Cell Biology
Yusuke Seto, Mototsugu Eiraku
Developmental Dynamics : an Official Publication of the American Association of Anatomists
H Isaac ChenGuo-Li Ming
Tissue Engineering and Regenerative Medicine
Hye-Jin JeongTae-Eun Park
© 2021 Meta ULC. All rights reserved