The application of carbon nanoparticles in the lymph node biopsy of cN0 papillary thyroid carcinoma: A randomized controlled clinical trial

Asian Journal of Surgery
Xiao Fan Xu, Jun Gu

Abstract

We applied carbon nanoparticle suspensions to the papillary thyroid carcinoma cases with no clinical regional lymph node metastasis (cN0) to show the lymph flow from primary tumors, and evaluated its value in the lymph node biopsy of cN0 papillary thyroid carcinoma and protection of parathyroid. One hundred and fourteen patients with cN0 papillary thyroid carcinoma were randomly assigned to experimental and control groups. The experimental group received carbon nanoparticles injection around the primary tumor, while the control group received no injection. Both groups subsequently received standard lateral thyroid gland resection, isthmus resection, subtotal thyroidectomy, or clearance of lymph nodes (LNs) of the central compartment. A total of 342 LNs of the central compartment were dissected in the experimental group (6.00 ± 0.98 per patient) with 81 LNs confirmed to be positive (0.95 ± 0.77 per patient), whereas 261 LNs of the same area were dissected in the control group (4.58 ± 0.60 per patient) with 27 confirmed to be positive (0.47 ± 0.50 per patient). There is a significant difference between experimental and control groups in the average number of LNs dissected per patient (6.00 ± 0.98 vs. 4.58 ± 0.60, p < 0.001) but n...Continue Reading

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