The application of click chemistry in the synthesis of agents with anticancer activity

Drug Design, Development and Therapy
Nan MaSheng Jiang

Abstract

The copper(I)-catalyzed 1,3-dipolar cycloaddition between alkynes and azides (click chemistry) to form 1,2,3-triazoles is the most popular reaction due to its reliability, specificity, and biocompatibility. This reaction has the potential to shorten procedures, and render more efficient lead identification and optimization procedures in medicinal chemistry, which is a powerful modular synthetic approach toward the assembly of new molecular entities and has been applied in anticancer drugs discovery increasingly. The present review focuses mainly on the applications of this reaction in the field of synthesis of agents with anticancer activity, which are divided into four groups: topoisomerase II inhibitors, histone deacetylase inhibitors, protein tyrosine kinase inhibitors, and antimicrotubule agents.

Citations

Jun 7, 2019·Chemical Biology & Drug Design·Nerella Sridhar GoudMallika Alvala
Jan 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biligma Tsyrenova, Valentine Nenajdenko
Feb 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela P S AlhoSilvia Marin
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Naiguo XingLing He
Jul 29, 2021·Bioconjugate Chemistry·Jasleen KaurNarayan Rishi
Apr 29, 2020·The Journal of Organic Chemistry·Biligma TsyrenovaValentine Nenajdenko

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Methods Mentioned

BETA
acetylation
xenograft
xenografts

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