The Application of Gail Model to Predict the Risk of Developing Breast Cancer among Jordanian Women

Journal of Oncology
Hikmat Abdel-RazeqShadi Hijjawi

Abstract

Background and Objectives. Breast cancer has been the most common cancer affecting women in Jordan. In the process of implementing breast cancer prevention and early detection programs, individualized risk assessment can add to the cost-effectiveness of such interventions. Gail model is a widely used tool to stratify patients into different risk categories. However, concerns about its applicability across different ethnic groups do exist. In this study, we report our experience with the application of a modified version of this model among Jordanian women. The Gail risk assessment model (RAM) was modified and used to calculate the 5-year and lifetime risk for breast cancer. Patients with known breast cancer were used to test this model. Medical records and hospital database were utilized to collect information on known risk factors. The mean calculated risk score for women tested was 0.65. This number, which corresponds to the Gail original score of 1.66, was used as a cutoff point to categorize patients as high risk. A total of 1786 breast cancer patients with a mean age of 50 (range: 19-93) years were included. The modified version of the Gail RAM was applied on 1213 patients aged 35-59.9 years. The mean estimated risk for de...Continue Reading

References

Sep 24, 1999·Journal of the National Cancer Institute·J P CostantinoH S Wieand
Feb 24, 2000·The New England Journal of Medicine·K ArmstrongB Weber
Feb 26, 2004·Cancer·Judith Salmon KaurPaul Novotny
May 29, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P BoyleC Robertson
Sep 29, 2004·Archives of Internal Medicine·Carmen L LewisRobert J Schwartz
Nov 29, 2007·Journal of the National Cancer Institute·Mitchell H GailLeslie Bernstein
Sep 24, 2010·The New England Journal of Medicine·Mette KalagerHans-Olov Adami
Nov 23, 2012·The New England Journal of Medicine·Robert A SmithMette Kalager
May 1, 2015·Breast Cancer Research : BCR·Magnus LøbergMette Kalager
Oct 27, 2015·JAMA : the Journal of the American Medical Association·Evan R MyersGillian D Sanders
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jun 14, 2017·Journal of Primary Care & Community Health·Abdulbari BenerWanis H Ibrahim

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Citations

Apr 15, 2021·Breast Cancer Research and Treatment·Basem SalehHadeer Mohamed

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Methods Mentioned

BETA
biopsies

Software Mentioned

SAS

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