The Application of Induced Pluripotent Stem Cells in Cardiac Disease Modeling and Drug Testing

Journal of Cardiovascular Translational Research
Lingqun YeShijun Hu

Abstract

In recent decades, cardiovascular diseases have become the greatest health threat to human beings, and thus it is particularly important to explore the subtle underlying pathogenesis of cardiovascular diseases. Although many molecular pathways have been explored to be essential in the development of cardiovascular diseases, their clinical significances are still uncertain. With the emergence of induced pluripotent stem cells (iPSCs), a unique platform for cardiovascular diseases has been established to model cardiovascular diseases on specific genetic background in vitro. This review summarizes current progresses of iPSCs in cardiovascular disease modeling and drug testing. This review highlighted iPSC-based cardiovascular disease modeling and drug testing. The technical advances in iPSC-based researches and various clinically relevant applications are discussed. With further intensive research, iPSC technology will shape the future of clinical translational research in cardiovascular diseases.

References

Jul 28, 2010·The New England Journal of Medicine·Alessandra MorettiKarl-Ludwig Laugwitz
Jan 18, 2011·Nature·Ilanit ItzhakiLior Gepstein
Feb 25, 2011·Nature·Guang-Hui LiuJuan Carlos Izpisua Belmonte
Apr 21, 2012·Science Translational Medicine·Ning SunJoseph C Wu
Aug 29, 2012·Journal of Pharmacological and Toxicological Methods·Fabio CerignoliMark Mercola
Jan 2, 2013·The Journal of General Physiology·Cecile TerrenoireRobert S Kass
Jan 29, 2013·Nature·Changsung KimHuei-Sheng Vincent Chen
Jun 29, 2013·Lab on a Chip·Ashutosh AgarwalKevin Kit Parker
Nov 10, 2013·Circulation. Cardiovascular Genetics·Oren CaspiLior Gepstein
Mar 4, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Andrea StoehrArne Hansen
May 6, 2014·Drug Discovery Today·Mohammad R EbrahimkhaniJeffrey T Borenstein
Aug 2, 2014·Journal of the American College of Cardiology·Yongming WangJoseph C Wu
Sep 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Clay W ScottMatthew F Peters
Mar 10, 2015·Scientific Reports·Anurag MathurKevin E Healy
Mar 12, 2015·EMBO Molecular Medicine·Michael GramlichAlessandra Moretti
May 20, 2015·Journal of Molecular and Cellular Cardiology·Hyun Seok HwangBjörn C Knollmann
Jun 1, 2015·Advanced Drug Delivery Reviews·Alexandra EderThomas Eschenhagen
Aug 18, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Roddy WalshHugh Watkins
Dec 13, 2016·Expert Opinion on Biological Therapy·Erik H Niks, Annemieke Aartsma-Rus

❮ Previous
Next ❯

Citations

Mar 25, 2019·Stem Cells International·Rosaria SantoroGiulio Pompilio
Feb 18, 2021·Pflügers Archiv : European journal of physiology·Yong WangShijun Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Y Z Xie, R X Zhang
© 2022 Meta ULC. All rights reserved