The Application of lncRNAs in Cancer Treatment and Diagnosis

Recent Patents on Anti-cancer Drug Discovery
Yi Zhang, Liling Tang

Abstract

It is increasingly evident that lncRNAs have various biological functions playing as essential regulators, getting involved in diverse cellular processes. Many of the lncRNAs show aberrant expression in cancer, which is associated with different cancer types. The dysregulation of lncRNAs has been increasingly linked to cancer carcinogenesis and progression. Due to their tissue-specific expression and key role in cancer, lncRNAs have the potential to be novel biomarkers or effective drug targets for cancer. This review aims to present the application of lncRNAs in cancer diagnosis and targeted cancer therapies, elaborates molecular mechanisms and provides a deeper understanding of cancer-related lncRNA functions. Relevant recent patents are collected to summarize the application of lncRNAs in cancer. Combined with published articles, functions and mechanisms of lncRNAs are elaborated. Patents revealed that a series of reagents and kits have been applied for early cancer diagnosis by detecting specific lncRNAs, having the advantages of high sensitivity, specificity and stability. In addition, lncRNAs as effective targets have been applied in developing targeted cancer drugs. With regard to their role in cancer, lncRNAs regulate t...Continue Reading

Citations

Mar 3, 2019·Journal of Cellular Biochemistry·Li FengYonggang Zhu
Jul 8, 2020·Non-coding RNA·Lucy GinnMichela Garofalo
Dec 11, 2019·The Pharmacogenomics Journal·Sorayya Ghasemi
Oct 9, 2019·Cancer Biomarkers : Section a of Disease Markers·Zhenhai JingQing Hong
May 28, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jie ZhangYanling Zhu
Dec 18, 2020·Frontiers in Medicine·Yuchen QianZhong Luo
Jun 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huan XiaXiaohong Lv

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