The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways

Current Drug Metabolism
Yan WangLulu Cai

Abstract

Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins abnormally expressed in apoptosis-related diseases, such as cancer. The majority of anti-cancer natural products promote apoptosis to induce cancer cell death. In this review, we aim to survey the current knowledge on key apoptotic proteins and some representative natural products that can induce cancer cell apoptosis by regulating these proteins. We reviewed the recent relative literatures using a structured search of bibliographic databases, and the keywords, such as natural products, cancer therapy, and apoptosis pathway, were used for inclusion/exclusion criteria. One hundred and seventy-one papers are included in this review. Numerous natural products have been reported to induce cell apoptosis by regulating the expression of key apoptotic proteins, leading to a variety of antitumor effects. This review identifies the major apoptotic proteins and elaborates the interaction between the apoptotic proteins and various natural anti-cancer products. This review provides substanti...Continue Reading

Citations

Mar 19, 2020·Natural Product Reports·Brice A P WilsonBarry R O'Keefe
Jan 14, 2020·Journal of Chemotherapy·Xue-Jun WangMei-Juan Yan
Aug 31, 2018·Journal of Applied Toxicology : JAT·Dejian YanYi Cao
May 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jiraporn KantapanNathupakorn Dechsupa
Aug 7, 2019·Dose-response : a Publication of International Hormesis Society·Yongqi LiangYi Cao
Feb 8, 2021·BMC Complementary Medicine and Therapies·Jia-Lu ZhengBing Hu
Mar 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kai ZhengZhendan He
Apr 13, 2021·Food Science & Nutrition·Yunyi ChenQingjun Chen
Jun 26, 2021·International Immunopharmacology·Qi Mu, Masoud Najafi

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