The application of observational data in translational medicine: analyzing tobacco-use behaviors of adolescents.

Journal of Translational Medicine
Valeria SicilianoSabrina Molinaro

Abstract

Translational Medicine focuses on "bench to bedside", converting experimental results into clinical use. The "bedside to bench" transition remains challenging, requiring clinicians to define true clinical need for laboratory study. In this study, we show how observational data (an eleven-year data survey program on adolescent smoking behaviours), can identify knowledge gaps and research questions leading directly to clinical implementation and improved health care. We studied gender-specific trends (2000-2010) in Italian students to evaluate the specific impact of various anti-smoking programs, including evaluation of perceptions of access to cigarettes and health risk. The study used, ESPAD-Italia® (European School Survey Project on Alcohol and other Drugs), is a nationally representative sample of high-school students. The permutation test for joinpoint regression was used to calculate the annual percent change in smoking. Changes in smoking habits by age, perceived availability and risk over a 11-year period were tested using a gender-specific logistic model and a multinomial model. Gender-stratified analysis showed 1) decrease of lifetime prevalence, then stabilization (both genders); 2) decrease in last month and occasiona...Continue Reading

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Citations

May 31, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Maria SoaresFernando Ferreira
Oct 19, 2012·Journal of Translational Medicine·Michael N Liebman, Sabrina Molinaro
Feb 12, 2013·Journal of Translational Medicine·Fan JiangXiaoming Shen
Jul 27, 2014·Journal of Gambling Studies·Mercedes GoriSabrina Molinaro
May 27, 2014·BioMed Research International·Lorena CharrierFranco Cavallo
Jan 22, 2017·European Journal of Public Health·Alessandro CoppoUNKNOWN PASSI Working Group
Jun 6, 2015·Culture, Health & Sexuality·Genaro Castro-Vázquez
Sep 1, 2013·Personalized Medicine·Michael N Liebman

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Software Mentioned

Joinpoint Regression
Joinpoint
ESPAD

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