The application of PET technique for the development and evaluation of novel antipsychotics

Current Pharmaceutical Design
Akihiro Takano

Abstract

Positron emission tomography (PET) is a useful technique to quantify various target molecules in vivo such as neuroreceptors, transporters and amyloid plaques using various successful radioligands. The technique has been widely used for the drug development in recent years. There are several approaches such as microdosing, measurement of in vivo receptor occupancy, and biomarkers. As for microdosing, the biodistrubution of the drugs in the human body could be evaluated in the very early phase of the drug development. The measurement of receptor occupancy in vivo could help to determine the optimal doses clinically before the large-scale clinical trials are performed, As biomarkers, radioligands could detect the pathological changes such as the accumulation of beta-amyloid and microglia. Especially the measurement of dopamine D2 receptor occupancy has been useful in the evaluation of antipsychotics. Based on it, the optimal clinical doses were evaluated and determined for the patients with schizophrenia. Although currently available antipsychotics have efficacy to the positive symptoms such as hallucination and delusion, they, regardless of the generations of antipsychotics, have only limited efficacy to the cognitive dysfunctio...Continue Reading

Citations

May 10, 2012·Journal of Biomedicine & Biotechnology·Lie-Hang ShenYu-Chin Tseng
Jan 4, 2012·Drug Delivery·Mine SilindirSuna Erdoğan
Sep 22, 2010·Advanced Drug Delivery Reviews·Zibo Li, Peter S Conti
Dec 3, 2014·Nuclear Medicine and Biology·Akina HaradaHaruhide Kimura
Jan 17, 2012·Neuron·David E J Linden
Jul 27, 2010·Schizophrenia Research·Rajiv TandonMatcheri S Keshavan
May 15, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Susana CunhaMaria Cristina Oliveira
Dec 14, 2017·Journal of Neuroendocrinology·R Moraga-AmaroE F J de Vries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

The British Journal of Radiology
P S MurphyA S K Dzik-Jurasz
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Mark P S Dunphy, Jason S Lewis
© 2021 Meta ULC. All rights reserved