The application of plasma tartrate-resistant acid phosphatase to assess changes in bone resorption in response to artificial menopause and its treatment with estrogen or norethisterone

Calcified Tissue International
J J StĕpánV Pacovský

Abstract

Plasma tartrate-resistant acid phosphatase (TR ACP), urinary hydroxyproline excretion (UH), serum osteocalcin, and bone alkaline phosphatase isozyme were determined in a prospective study in 31 women who had undergone bilateral ovariectomy (OOX). Nine patients were followed up for 1 year without treatment and for the following 3 years when on mestranol (M) substitution. On the basis of UH, 22 patients were identified as having increased bone resorption (BR) within 3 months of OOX. Subsequently, 11 patients were treated with transdermal estradiol (E2) and 11 patients with norethisterone (norethindrone, NE). In untreated patients, the biochemical indices of BR peaked 3-6 months following OOX and biochemical indices of bone formation (BF) continued to increase from 3 until 12 months. The substitution with both E2 or M resulted in normalization in serum and urinary calcium, serum phosphate, renal threshold phosphate concentration (TmPO4/GRF), and biochemical indices of BR within 4 months of treatment. Biochemical indices of BF normalized within 6 months of treatment. In the M-treated group, these effects continued for 3 years of the follow-up. The hormonal substitution had a protective effect on cortical and lumbar spine bone mass....Continue Reading

References

May 17, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·J StĕpánJ Kolár
Aug 16, 1975·Lancet·R J Walton, O L Bijvoet
Feb 1, 1989·Calcified Tissue International·M L SmithI Leggate
Feb 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S H AllenR M Roberts
May 16, 1987·Lancet·C ChristiansenP Rødbro
Jun 19, 1986·The New England Journal of Medicine·R J ChetkowskiH L Judd
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J J StĕpánV Pacovský
Nov 1, 1987·The Journal of Clinical Investigation·C SlemendaC C Johnston
Jan 1, 1987·Annals of Internal Medicine·B EttingerC E Cann
Oct 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J StĕpánV Pacovský
Jan 1, 1972·Clinical Endocrinology·J C GallagherB E Nordin
Jan 1, 1972·Clinical Endocrinology·J J Legros, P Franchimont
Jan 1, 1974·American Journal of Clinical Pathology·L G Morin
Jul 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·J DubovskýV Pacovský
Jul 15, 1983·Analytical Biochemistry·D A BenciniG A O'Donovan
Sep 30, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J StĕpanV Pacovský
Dec 8, 1983·The New England Journal of Medicine·A HorsmanC Nordin
Feb 4, 1964·Archiv für Gynäkologie·M HENZLJ PRESL

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Citations

Apr 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C P JeromeM R Adams
May 1, 1993·Calcified Tissue International·H RicoI Arribas
Nov 17, 2009·Calcified Tissue International·Anthony J Janckila, Lung T Yam
May 23, 2006·Rheumatology International·Alper HayirliogluNurten Andaç
Apr 21, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C Castelo-BrancoJ González-Merlo
Oct 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·L P Schot, A H Schuurs
Mar 20, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M NozakiH Nakano
Jan 27, 1996·Lancet·A J Simpson, M Elstein
Feb 28, 2002·Journal of Clinical Pharmacology·Patrick GarneroKenneth V Phelps
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C PriorL Atley
Nov 26, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A G Ederveen, H J Kloosterboer
Mar 18, 2009·The Journal of Pathology·Helen J Knowles, Nicholas A Athanasou
Jun 15, 1993·Analytical Chemistry·N A McCarroll
Feb 14, 2006·Journal of Cellular Biochemistry·Barrie KirsteinKaren Fuller
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yoshihiko IgarashiShigeru Matsuzaki

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