The application of positron emission tomography/computed tomography in radiation treatment planning: effect on gross target volume definition and treatment management

Clinical Oncology : a Journal of the Royal College of Radiologists
S IğdemS Okkan

Abstract

To analyse the effect of the use of molecular imaging on gross target volume (GTV) definition and treatment management. Fifty patients with various solid tumours who underwent positron emission tomography (PET)/computed tomography (CT) simulation for radiotherapy planning from 2006 to 2008 were enrolled in this study. First, F-18 fluorodeoxyglucose (FDG)-PET and CT scans of the treatment site in the treatment position and then a whole body scan were carried out with a dedicated PET/CT scanner and fused thereafter. FDG-avid primary tumour and lymph nodes were included into the GTV. A multidisciplinary team defined the target volume, and contouring was carried out by a radiation oncologist using visual methods. To compare the PET/CT-based volumes with CT-based volumes, contours were drawn on CT-only data with the help of site-specific radiologists who were blind to the PET/CT results after a median time of 7 months. In general, our PET/CT volumes were larger than our CT-based volumes. This difference was significant in patients with head and neck cancers. Major changes (> or =25%) in GTV delineation were observed in 44% of patients. In 16% of cases, PET/CT detected incidental second primaries and metastatic disease, changing the ...Continue Reading

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Citations

May 18, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·R J D PrestwichA F Scarsbrook
Aug 26, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·Stephen Falk
Apr 2, 2015·PET Clinics·Minh Tam Truong, Nataliya Kovalchuk
Dec 5, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Judit A AdamWouter V Vogel

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