The application of RNAi-based treatments for inflammatory bowel disease

Drug Delivery and Translational Research
Morten Tobias Jarlstad OlesenKenneth Alan Howard

Abstract

Inflammatory bowel disease (IBD) is a chronic, relapsing, idiopathic inflammation of the gastrointestinal tract with no permanent cure. Present immunosuppressive and anti-inflammatory therapies are often ineffective and associated with severe side effects. An RNA interference (RNAi)-based approach in which small interfering RNA (siRNA) mediates specific downregulation of key molecular targets of the IBD inflammatory process may offer a precise, potent and safer alternative to conventional treatments. This review describes the aetiology of Crohn's disease and ulcerative colitis and the cellular and molecular basis for current treatments to highlight target candidates for an RNAi-based approach. Promising preclinical studies support an RNAi application; however, optimal siRNA designs that maximise potency and development of enabling technologies for site- and cellular-specific delivery are prerequisites for clinical translation.

References

Aug 1, 1990·The Journal of Allergy and Clinical Immunology·A SaxonS Targan
Oct 15, 1989·Annals of Internal Medicine·D H PresentB I Korelitz
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·M K MontgomeryA Fire
Sep 29, 1999·Trends in Biochemical Sciences·T E Dever
Mar 22, 2001·Advanced Drug Delivery Reviews·C W Pouton, L W Seymour
Jul 19, 2001·Nature·P M WaterhouseT Lough
Sep 21, 2001·Alimentary Pharmacology & Therapeutics·P J Rutgeerts
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·B R Williams
Feb 28, 2002·Annual Review of Immunology·Warren StroberRichard S Blumberg
Mar 23, 2002·Science·Thijn R BrummelkampReuven Agami
May 23, 2002·Science·Hongwei LiShou Wei Ding
Jun 18, 2002·Digestive Diseases and Sciences·J WehkampK Fellermann
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Jan 16, 2003·Nucleic Acids Research·Mohammed AmarzguiouiHans Prydz
May 29, 2003·Nucleic Acids Research·Frank CzaudernaJörg Kaufmann
Jul 2, 2003·Biochemistry·Dwaine A BraaschDavid R Corey
Jul 24, 2003·Nature Reviews. Immunology·Gerd Bouma, Warren Strober
Aug 19, 2003·RNA·Ya-Lin Chiu, Tariq M Rana
Aug 28, 2003·Nature Cell Biology·Carol A SledzBryan R G Williams
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 17, 2004·PLoS Biology·Zhixin XieJames C Carrington
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stephen Mark TompkinsSuzanne L Epstein
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qing GeJianzhu Chen
Jun 5, 2004·Gastroenterology Clinics of North America·Kim L Isaacs, R Balfour Sartor
Jun 29, 2004·Trends in Genetics : TIG·Nadine L Vastenhouw, Ronald H A Plasterk
Jul 10, 2004·Cell·Haidi ZhangWitold Filipowicz
Sep 17, 2004·Nature·Gunter Meister, Thomas Tuschl
Nov 16, 2004·Mechanisms of Ageing and Development·Kathleen A Smoak, John A Cidlowski
Dec 28, 2004·Nature Biotechnology·Dong-Ho KimJohn J Rossi
Jan 5, 2005·Nature Reviews. Genetics·Marjori A Matzke, James A Birchler
Jan 18, 2005·Nucleic Acids Research·Joacim ElménClaes Wahlestedt
Mar 9, 2005·Biochemical and Biophysical Research Communications·Zheng-Yin LiDavid G Gorenstein
Mar 22, 2005·Nature Biotechnology·Adam D JudgeIan MacLachlan
Apr 13, 2005·The Journal of Experimental Medicine·Christel RousseauxPierre Desreumaux

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Citations

Dec 25, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Annika FredeAstrid M Westendorf
Feb 25, 2021·Research : a Science Partner Journal·Rani MataChangyou Gao
May 25, 2021·Essays in Biochemistry·Morten T Jarlstad Olesen, Lasse S Kristensen

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