The application of stem cell therapy and brown adipose tissue transplantation in metabolic disorders.

Cytotherapy
Kang-Yun LuShih-Ping Liu

Abstract

The discovery of brown fat in adult humans has led to increased research of the thermogenic function of this tissue in various metabolic diseases. In addition, high levels of brown fat have been correlated with lower body mass index values. Therefore, increasing brown fat mass and/or activity through methods such as the browning of white fat is considered a promising strategy to prevent and treat obesity-associated diseases. Cell-based approaches using mesenchymal stromal cells and brown adipose tissue (BAT) have been utilized to directly increase BAT mass/activity through cell and tissue implantation into animals. In addition, recent studies evaluating the transplantation of human embryonic stem cells and induced pluripotent stem (iPS) cells have shown promising results in terms of positive metabolic function. In this comprehensive review, we provide a summary of the research over the past 10 years with regard to stem cell therapy and brown fat tissue transplantation for the effective treatment of metabolic syndrome. Recent advancements in stem cell methods have allowed for the production of brown adipocytes from human iPS cells, which represent an unlimited source of cellular material with which to study adipocyte development...Continue Reading

Citations

Oct 19, 2020·Stem Cell Reviews and Reports·Akram NadiShiva Asadpour
Feb 2, 2021·Medicinal Research Reviews·Milena DeptułaMichał Pikuła
Mar 2, 2021·Frontiers in Pharmacology·Gabriela Reolon PassosFabiola Zakia Mónica
Jul 3, 2021·Biomolecules·Anna Trzyna, Agnieszka Banaś-Ząbczyk

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