The application of terahertz pulsed imaging in characterising density distribution of roll-compacted ribbons

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Jianyi ZhangChuan-Yu Wu

Abstract

Roll compaction is a commonly used dry granulation process in pharmaceutical, fine chemical and agrochemical industries for materials sensitive to heat or moisture. The ribbon density distribution plays an important role in controlling properties of granules (e.g. granule size distribution, porosity and strength). Accurate characterisation of ribbon density distribution is critical in process control and quality assurance. The terahertz imaging system has a great application potential in achieving this as the terahertz radiation has the ability to penetrate most of the pharmaceutical excipients and the refractive index reflects variations in density and chemical compositions. The aim of this study is to explore whether terahertz pulse imaging is a feasible technique for quantifying ribbon density distribution. Ribbons were made of two grades of microcrystalline cellulose (MCC), Avicel PH102 and DG, using a roll compactor at various process conditions and the ribbon density variation was investigated using terahertz imaging and section methods. The density variations obtained from both methods were compared to explore the reliability and accuracy of the terahertz imaging system. An average refractive index is calculated from the...Continue Reading

References

Mar 12, 2005·Journal of Pharmaceutical Sciences·Anthony J FitzgeraldPhilip F Taday
Aug 28, 2007·Journal of Pharmaceutical Sciences·John A SpencerAjaz Husain
Dec 7, 2007·Journal of Pharmaceutical and Biomedical Analysis·Ryanne PalermoPhilip F Taday
Jan 10, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andres M Miguélez-MoránJonathan P K Seville
Apr 16, 2009·Journal of Pharmaceutical Sciences·Louise HoJ Axel Zeitler
Apr 24, 2013·Journal of Pharmaceutical Sciences·Robert K MayJ Axel Zeitler

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Citations

Jun 8, 2018·Annual Review of Chemical and Biomolecular Engineering·Christopher L BurchamMartin D Johnson

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