PMID: 616030Feb 1, 1977Paper

The application of the Reaction Rate Analyser LKB 8600 as an automatic coagulometer

Scandinavian Journal of Clinical and Laboratory Investigation
I Andersen, S Thorsen

Abstract

The application of the Reaction Rate Analyser LKB 8600 (RRA) as an automatic coagulometer is described. The RRA was slightly modified without interfering with its function as an enzyme reaction rate analyser. The endpoint of coagulation was recorded when the increase in absorbance exceeded 0.047 at lambda = 340 nm. The coagulation time was monitored by a counter with automatic print-out or by a recorder. The analytical dispersion, s(x)x, ranged between 0.01 and 0.05. Results (x, y) of the determination of the quantity of plasma coagulation factors (II + VII + X) by RRA and manually by visual recording could be expressed by y = 0.93x + 0.04, r = 0.96, n = 66 (method of Owren & Aas) or by y = 1.00x + 0.02, r = 0.98, n = 49 (Normotest). Similarly, plasma activated partial thromboplastin time (Activated Thrombofax) could be expressed by y = 0.99x + 5.00, r = 0.99, n = 23.

Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·J BondeJ P Kampmann
Jun 1, 1988·Journal of Biochemical and Biophysical Methods·F C CelentanoP G Righetti
Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·D VlaskouA Dionyssiou-Asteriou
Nov 1, 1989·Acta Physiologica Scandinavica·L E AppelgrenP J Wistrand
Oct 15, 1987·Thrombosis Research·H FrandsenE Scheibel

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