The application of tissue engineering procedures to repair the larynx

Journal of Speech, Language, and Hearing Research : JSLHR
Robert L RingelS F Badylak

Abstract

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice, and hearing. The present manuscript describes a study that was conducted in which a biologic scaffold derived from porcine (pig) extracellular matrix (ECM) was used to repair the defect following a hemilaryngectomy procedure in dogs. The ECM-augmented repair was compared with a control standard strap muscle (STM) procedure. The animals were sacrificed after 24 weeks at which time anatomic and histologic analyses were conducted. The ECM repair resulted in a macroscopic and microscopic reconstruction of laryngeal tissue that was superior to that observed with the STM procedure. The importance of regenerated tissue having the same structural and functional characteristics of native tissue is emphasized. A discussion of the mechanisms of ECM remodeling is presented along with the implications of such remodeling in the repair of laryngeal structures.

References

Jul 1, 1989·The Journal of Surgical Research·S F BadylakL A Geddes
Jan 1, 1974·Anesthesiology·B R Fink
Apr 1, 1974·Acta Oto-laryngologica·B R Fink
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A Matter, L Müller
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·C OstlundB Olsson
Sep 1, 1983·Pflügers Archiv : European journal of physiology·C Fromm
Jun 1, 1984·Journal of Speech and Hearing Research·A L PerlmanD S Cooper
Sep 1, 1993·Archives of Otolaryngology--head & Neck Surgery·I SandersH F Biller
Apr 1, 1995·The Journal of Surgical Research·G E SanduskyS F Badylak
Apr 1, 1997·The Annals of Otology, Rhinology, and Laryngology·R J AndrewsG S Berke
May 20, 1998·The Laryngoscope·R W Chan, I R Titze
Nov 7, 1998·The Journal of Thoracic and Cardiovascular Surgery·M C Robotin-JohnsonJ L Cox
Nov 20, 1998·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·H NakagawaJ Kanzaki
Jun 16, 1999·The Laryngoscope·S D GrayT H Hammond
Jul 13, 1999·The Laryngoscope·R W Chan, I R Titze
Sep 25, 1999·The American Journal of Sports Medicine·J L CookC R Cook
Oct 26, 1999·The Journal of the Acoustical Society of America·R W Chan, I R Titze
Jun 13, 2000·Nature·P Smaglik
Jun 16, 2000·The Annals of Otology, Rhinology, and Laryngology·J JiangD Hanson
Feb 15, 2001·JAMA : the Journal of the American Medical Association·L E Niklason, R Langer
Jun 8, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R W ChanI R Titze
Jun 21, 2001·Endothelium : Journal of Endothelial Cell Research·J P HoddeS F Badylak
Nov 8, 2001·Experimental Hematology·S F BadylakM Yoder
Jan 5, 2002·The Annals of Otology, Rhinology, and Laryngology·N TayamaI R Titze
Mar 12, 2002·Tissue Engineering·Ayda SarikayaMichael Ladisch
Jun 6, 2003·The Annals of Otology, Rhinology, and Laryngology·Jessica E HuberStephen Badylak
Dec 5, 2003·The Annals of Otology, Rhinology, and Laryngology·Shin-Ichi KanemaruYasuhiko Shimizu
Apr 6, 2004·The Laryngoscope·Susan L ThibeaultDiane M Bless
Apr 9, 2004·Journal of Voice : Official Journal of the Voice Foundation·Bernard RousseauDiane M Bless
May 26, 2004·Transplant Immunology·Stephen F Badylak
Sep 17, 2004·Endothelium : Journal of Endothelial Cell Research·F LiS Badylak
Nov 13, 2004·The Annals of Otology, Rhinology, and Laryngology·Shigeru HiranoCharles N Ford
May 18, 2005·The Annals of Otology, Rhinology, and Laryngology·Shigeru HiranoDiane M Bless

❮ Previous
Next ❯

Citations

Dec 17, 2008·Tissue Engineering. Part a·Susan L ThibeaultGlenn Prestwich
Apr 3, 2009·Tissue Engineering. Part B, Reviews·Jaishankar K Kutty, Ken Webb
Feb 15, 2012·Annals of Surgery·Giuseppe OrlandoShay Soker
Apr 19, 2008·Journal of Biomaterials Science. Polymer Edition·John J StankusWilliam R Wagner
Oct 29, 2013·Tissue Engineering. Part a·Bernard GrevemeyerBryan N Brown
Sep 25, 2014·BioMed Research International·Silvia BaigueraCostantino Del Gaudio
Jul 17, 2012·Journal of Voice : Official Journal of the Voice Foundation·Markus GugatschkaShigeru Hirano
Apr 9, 2011·Biomaterials·Silvia BaigueraPaolo Macchiarini
Jan 30, 2008·Journal of Biomedical Materials Research. Part a·Donald O FreytesStephen F Badylak
Aug 4, 2015·Acta Biomaterialia·Stephen F BadylakThomas W Gilbert
Mar 27, 2010·The Annals of Otology, Rhinology, and Laryngology·Masaru YamashitaJuichi Ito
Feb 14, 2017·Stem Cells Translational Medicine·Tahera AnsariMartin A Birchall
Jan 19, 2021·ACS Biomaterials Science & Engineering·Camilo Mora-NavarroDonald O Freytes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.