The Approach to Solitary Fibrous Tumors: Are Clinicopathological Features and Nomograms Accurate in the Prediction of Prognosis?

International Journal of Surgical Pathology
Deanna Wan Jie NgMelissa Ching Ching Teo

Abstract

Currently, factors such as size, mitotic rate, and degree of necrosis have been shown to influence survival in patients with solitary fibrous tumors (SFTs); however, there remains no consensus regarding the associations between tumor characteristics and the malignant nature of these tumors. The aim of this article was to identify factors that would help in prognosticating SFTs and to validate the MD Anderson Cancer Center (MDACC) SFT nomogram in the largest known series of SFTs treated in an Asian population. A retrospective review of all patients with a diagnosis of SFT treated surgically in our institution between 2005 and 2015 was carried out. Basic demographics, clinicopathological, and surgical factors were analyzed for association with clinical outcomes. Factors that predicted for distant recurrence (DR) and poor survival were identified as high-risk features. The MDACC nomogram was validated by assessing the extent of discrimination, quantified using Harrell's concordance index (C-index). Fifty-nine patients were included in analysis. Significant univariate associations for DR were found for mitotic rate ( P = .05) and presence of necrosis ( P = .04). Significant univariate associations for overall survival were found fo...Continue Reading

References

Aug 1, 1989·The American Journal of Surgical Pathology·D M EnglandM J McCarthy
Jul 18, 2002·The Annals of Thoracic Surgery·Marc de PerrotShaf Keshavjee
Jan 12, 2005·The Journal of Urology·Brent V YankeMichael W Kattan
Dec 20, 2005·Histopathology·C Gengler, L Guillou
Nov 1, 2006·Cancer Control : Journal of the Moffitt Cancer Center·Lary A Robinson
May 16, 2009·Current Opinion in Oncology·Min S Park, Dejka M Araujo
Oct 27, 2009·The Annals of Thoracic Surgery·Giuseppe CardilloMassimo Martelli
May 12, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elizabeth G DemiccoWei-Lien Wang
Jun 19, 2012·The Annals of Thoracic Surgery·Benoit LahonPhilippe Dartevelle
Sep 21, 2013·Annals of Surgical Oncology·Winan J van HoudtThijs van Dalen
May 8, 2014·World Journal of Gastroenterology : WJG·Xue-Ming LiGuo-Hui Xu
Aug 15, 2014·BMC Pulmonary Medicine·Daniel FranzenMalcolm Kohler
Jan 27, 2015·The Annals of Thoracic Surgery·Guillaume BoddaertMarc Riquet
Mar 1, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S PasqualiA Desai

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
SMA

Software Mentioned

R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua zhong liu za zhi [Chinese journal of oncology]
Jian-peng LiZhi-jun Geng
Annals of Surgical Oncology
Winan J van HoudtThijs van Dalen
Annals of Oncology : Official Journal of the European Society for Medical Oncology
S StacchiottiP G Casali
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Wen-bo XiaoLing-yu Ge
© 2022 Meta ULC. All rights reserved