Mar 16, 2016

The aptabot: an inducibly affinity-switching, minimally invasive in vivo contrast agent

BioRxiv : the Preprint Server for Biology
Elleard HeffernRussell Hanson

Abstract

The ambitions of current neuroscience, understanding neurological disease progression and mapping the connectome, demonstrate a need for safe in vivo tools for creating intricate maps of brain circuitry. Present in vivo contrast agents are often limited by their specificity, uptake, resolvability, and/or clearance. We describe an aptamer-functionalized sensor for high-resolution imaging that can switch imaging targets by an induced multi-stage aptamer reaction. Included are synthetic methods as well as calculations of sensor efficacy based on known kinetics. Calculations show that 10 distinct targets may be imaged in a living brain at the submicron scale within 42 hours.

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Mentioned in this Paper

In Vivo
Connectome
Brain
Uptake
Pharmacologic Substance
Contrast Media
Aptamer
Diagnostic Imaging
Disease Progression

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