PMID: 9193450May 1, 1997Paper

The aquaporin family of water channel proteins in clinical medicine

Medicine
M D LeeP Agre

Abstract

The aquaporins are a family of membrane channel proteins that serve as selective pores through which water crosses the plasma membranes of many human tissues and cell types. The sites where aquaporins are expressed implicate these proteins in renal water reabsorption, cerebrospinal fluid secretion and reabsorption, generation of pulmonary secretions, aqueous humor secretion and reabsorption, lacrimation, and multiple other physiologic processes. Determination of the aquaporin gene sequences and their chromosomal locations has provided insight into the structure and pathophysiologic roles of these proteins, and primary and secondary involvement of aquaporins is becoming apparent in diverse clinical disorders. Aquaporin-1 (AQP1) is expressed in multiple tissues including red blood cells, and the Colton blood group antigens represent a polymorphism on the AQP1 protein. AQP2 is restricted to renal collecting ducts and has been linked to congenital nephrogenic diabetes insipidus in humans and to lithium-induced nephrogenic diabetes insipidus and fluid retention from congestive heart failure in rat models. Congenital cataracts result from mutations in the mouse gene encoding the lens homolog Aqp0 (Mip). The present understanding of a...Continue Reading

References

Nov 27, 1992·Science·H HasegawaA S Verkman
Dec 1, 1992·The American Journal of Physiology·I SabolićD Brown
May 15, 1992·Biochemical and Biophysical Research Communications·A N Van HoekJ A Dempster
Sep 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·T H Milhorat
Sep 1, 1990·The Journal of General Physiology·G R EhringJ E Hall
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G M Preston, P Agre
Feb 20, 1992·Nature·C Anderson
May 1, 1990·Mayo Clinic Proceedings·M K Lyons, F B Meyer
Jun 1, 1989·The Journal of Cell Biology·G A ZampighiS A Simon
Jun 26, 1989·Biochimica Et Biophysica Acta·L W FungM P Westerman
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J FischbargJ Loike
Jan 1, 1986·Annual Review of Genetics·N Maeda, O Smithies
Jun 1, 1985·The Journal of Clinical Investigation·S ChristensenT P Dousa
Feb 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S A ErnstG J Siegel
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A M SabooriP Agre
Nov 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R BotonD C Batlle
Oct 1, 1974·The Journal of Clinical Investigation·R M Effros
Jul 7, 1970·Biochimica Et Biophysica Acta·R I Macey, R E Farmer
Feb 1, 1967·Journal of Applied Physiology·N C StaubM L Pearce
Jan 1, 1983·Annals of the New York Academy of Sciences·A K SolomonA S Verkman
Jan 1, 1981·Annals of the New York Academy of Sciences·J B WadeS A Lewis
Dec 8, 1995·The Journal of Biological Chemistry·G CalamitaP Agre
Aug 1, 1995·Current Opinion in Cell Biology·P AgreS Nielsen
Oct 1, 1995·Cancer Genetics and Cytogenetics·G Bepler, A Koehler
Dec 15, 1993·Biochemical and Biophysical Research Communications·T MaA S Verkman
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·H G FolkessonA S Verkman
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A Knepper
Sep 1, 1994·The Journal of Clinical Investigation·B L SmithP Agre
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·S R DiGiovanniM A Knepper
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M EchevarriaG Frindt
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y AsahinaC Sato
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·S K RobertsN F LaRusso

❮ Previous
Next ❯

Citations

Nov 7, 2000·Molecular Reproduction and Development·H OffenbergA J Watson
Sep 20, 2005·Pflügers Archiv : European journal of physiology·Peter Steen PedersenOle Frederiksen
Nov 27, 1998·The American Journal of Medicine·D G Bichet
Aug 28, 1998·Current Opinion in Cell Biology·P M Deen, C H van Os
Jun 17, 2000·Biochimica Et Biophysica Acta·D L Daleke, J V Lyles
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J K SmithS L Berk
Aug 24, 2002·Biology of Reproduction·M HagedornB S Pukazhenthi
Feb 22, 2001·Annual Review of Physiology·J P Morello, D G Bichet
Dec 30, 1999·American Journal of Respiratory Cell and Molecular Biology·J E TowneA G Menon
May 17, 2000·The Journal of Clinical Investigation·H MatsuiR C Boucher
Aug 7, 2013·Clinical Proteomics·Renu GoelAkhilesh Pandey
Apr 2, 2008·Medicine and Science in Sports and Exercise·Stephen A InghamJonathan H Doust
Apr 15, 2008·Medicine and Science in Sports and Exercise·D Enette Larson-MeyerEric Ravussin
Jun 27, 2008·Medicine and Science in Sports and Exercise·Shannan E GormleyRamya Gandrakota
Nov 17, 2009·Medicine and Science in Sports and Exercise·Jonathan H TremblayDenis Massicotte
Dec 3, 2009·Medicine and Science in Sports and Exercise·Chris ConnaboyRoss Sanders
Apr 25, 2012·Medicine and Science in Sports and Exercise·Tyler M FarneyRichard J Bloomer
Jan 1, 2013·Medicine and Science in Sports and Exercise·Cecilia BellottiSilvia Pogliaghi
Apr 18, 2013·Medicine and Science in Sports and Exercise·Thibaut GuiraudAtul Pathak
Sep 27, 2002·Journal of Veterinary Internal Medicine·Michele Cohen, Gerald S Post
Apr 7, 2005·Brain Research Bulletin·Francesca BosettiPachiappan Manickam
Nov 10, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S L LanceM Hagedorn
Apr 27, 2007·Differentiation; Research in Biological Diversity·Rupalatha MaddalaPonugoti Vasantha Rao
Aug 6, 2000·Japanese Journal of Pharmacology·Y Ishikawa, H Ishida
Jan 31, 2003·Respiratory Medicine·K W TsangK N Lai
Jul 26, 2002·Microbial Pathogenesis·Takashi HamabataYoshifumi Takeda
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jérôme BadautLuca Regli
Oct 26, 2010·Molecular Pain·Guang-Yin XuJin Tao
Nov 5, 2003·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Ana B Chepelinsky
Jan 15, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Most Nahid ParvinKazuo Hosoi
Sep 5, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Min Jeong Ji, Jeong Hee Hong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.