The Arabidopsis RING-type E3 ligase XBAT32 mediates the proteasomal degradation of the ethylene biosynthetic enzyme, 1-aminocyclopropane-1-carboxylate synthase 7

The Plant Journal : for Cell and Molecular Biology
Wendy LyzengaSophia L Stone

Abstract

E3 ubiquitin ligases select specific proteins for ubiquitin conjugation, and the modified proteins are commonly degraded through the 26S proteasome. XBAT32 is a RING-type E3 ligase involved in maintaining appropriate levels of ethylene. Previous work has suggested that XBAT32 modulates ethylene production by ubiquitinating two ethylene biosynthesis enzymes, ACS4 (type-II isoform) and ACS7 (type-III isoform). In Arabidopsis, conserved sequences within the C-terminal tail of type-I and -II 1-aminocyclopropane-1-carboxylate (ACC) synthase (ACS) isoforms influence ubiquitin-dependent proteolysis. ACS7, the sole Arabidopsis type-III ACS, contains a truncated C-terminal tail that lacks all known regulatory sequences, which suggests that this isoform may not be subject to ubiquitin-mediated proteasomal degradation. Here we demonstrate in planta that ACS7 is turned over in a 26S proteasome-dependent manner and that degradation of ACS7 requires the E3 ligase XBAT32. Furthermore, the ethylene-related phenotypes that result from overexpression of ACS7 in wild-type plants are greatly exaggerated in xbat32-1, suggesting that XBAT32 is required to attenuate the effect of overexpression of ACS7. This observation is consistent with a role for ...Continue Reading

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Citations

Jun 23, 2012·Plant Physiology·Dior R Kelley, Mark Estelle
Mar 21, 2013·The Plant Cell·Gyeong Mee Yoon, Joseph J Kieber
Jun 4, 2013·Annual Review of Phytopathology·Robert Dudler
Aug 15, 2013·Journal of Experimental Botany·Shih-Jhe HuangIng-Feng Chang
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Jun 23, 2015·Molecules and Cells·Gyeong Mee Yoon
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Dec 19, 2014·Frontiers in Plant Science·Maria A RodriguesLuciano Freschi
Nov 27, 2014·Frontiers in Plant Science·Bram Van de Poel, Dominique Van Der Straeten
Jul 20, 2016·Molecular Biology International·Niaz Mahmood, Nahid Tamanna
Apr 26, 2017·The Plant Journal : for Cell and Molecular Biology·Han Yong LeeGyeong Mee Yoon
Mar 8, 2018·Journal of Experimental Botany·Valter Miotto AlessioMarcelo Menossi
Mar 9, 2018·Molecular & Cellular Proteomics : MCP·Dior R Kelley
Feb 10, 2018·Journal of Experimental Botany·Nan MaJunping Gao
Nov 19, 2015·Frontiers in Plant Science·M I R KhanNafees A Khan
Jan 11, 2020·Frontiers in Plant Science·Joanna K Polko, Joseph J Kieber
Nov 6, 2018·Frontiers in Plant Science·Chi-Kuang WenYong-Ling Ruan
Aug 25, 2020·Plant Signaling & Behavior·Han Yong Lee, Gyeong Mee Yoon
Nov 17, 2020·Frontiers in Plant Science·Juan-Ying ZhaoDong-Hong Min
Aug 14, 2020·The New Phytologist·Jolien PattynBram Van de Poel
Feb 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dongdong HaoHongwei Guo

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