The ArcB sensor kinase of Escherichia coli autophosphorylates by an intramolecular reaction.

Journal of Bacteriology
Gabriela R Peña-Sandoval, Dimitris Georgellis

Abstract

The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory conditions of growth. ArcB is a tripartite histidine kinase whose activity is regulated by the oxidation of two cytosol-located redox-active cysteine residues that participate in intermolecular disulfide bond formation. Here we show that ArcB autophosphorylates through an intramolecular reaction which diverges from the usually envisaged intermolecular autophosphorylation of homodimeric histidine kinases.

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Citations

Jun 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Angel E DagoHendrik Szurmant
Nov 22, 2011·Antioxidants & Redox Signaling·Emilio BuenoMaria J Delgado
Oct 16, 2012·Applied and Environmental Microbiology·Gonzalo N BidartPablo I Nikel
Jun 6, 2012·PloS One·Luis Alberto Nuñez OrezaDimitris Georgellis
Dec 4, 2015·Molecular Plant·Blanka PekárováJan Hejátko
Jan 22, 2013·Journal of Molecular Biology·Orr AshenbergMichael T Laub
Sep 19, 2015·Canadian Journal of Microbiology·Minh-Phuong NguyenSang-Won Lee
Jan 15, 2015·Molecular Microbiology·Allison N Norsworthy, Karen L Visick
Apr 16, 2015·Microbiology·TuAnh Ngoc HuynhValley Stewart
Oct 19, 2010·Current Opinion in Structural Biology·Patricia CasinoAlberto Marina
May 29, 2016·Environmental Microbiology·Adrian F AlvarezDimitris Georgellis
Aug 16, 2016·Journal of Molecular Biology·Christopher P ZschiedrichHendrik Szurmant
Jun 28, 2018·The Journal of Biological Chemistry·Juan L Teran-MeloDimitris Georgellis
Dec 12, 2018·The Biochemical Journal·Trisiani Affandi, Megan M McEvoy
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pikyee Ma, Mary K Phillips-Jones

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