The Arden Syntax standard for clinical decision support: experiences and directions

Journal of Biomedical Informatics
Matthias SamwaldKlaus-Peter Adlassnig

Abstract

Arden Syntax is a widely recognized standard for representing clinical and scientific knowledge in an executable format. It has a history that reaches back until 1989 and is currently maintained by the Health Level 7 (HL7) organization. We created a production-ready development environment, compiler, rule engine and application server for Arden Syntax. Over the course of several years, we have applied this Arden - Syntax - based CDS system in a wide variety of clinical problem domains, such as hepatitis serology interpretation, monitoring of nosocomial infections or the prediction of metastatic events in melanoma patients. We found the Arden Syntax standard to be very suitable for the practical implementation of CDS systems. Among the advantages of Arden Syntax are its status as an actively developed HL7 standard, the readability of the syntax, and various syntactic features such as flexible list handling. A major challenge we encountered was the technical integration of our CDS systems in existing, heterogeneous health information systems. To address this issue, we are currently working on incorporating the HL7 standard GELLO, which provides a standardized interface and query language for accessing data in health information s...Continue Reading

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Citations

Aug 9, 2012·Journal of the American Medical Informatics Association : JAMIA·Jeroen S de BruinWalter Koller
Jun 3, 2014·Sensors·Asad Masood KhattakSungyoung Lee
Apr 9, 2014·IEEE Journal of Biomedical and Health Informatics·Robert VargaAndrew Hamilton-Wright
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Jul 4, 2012·Journal of Biomedical Informatics·Elizabeth S ChenIndra Neil Sarkar
Nov 26, 2015·Artificial Intelligence in Medicine·Stefan KrausDennis Toddenroth
Nov 18, 2015·Artificial Intelligence in Medicine·Maqbool HussainKhalid Latif
Jan 7, 2015·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Maqbool HussainKhalid Latif
Dec 10, 2014·Journal of Medical Systems·Bianying SongMichael Marschollek
Jun 20, 2016·Artificial Intelligence in Medicine·Chai Young JungSukil Kim
Jul 13, 2016·Journal of Biomedical Informatics·Luis Marco-RuizJ Gustav Bellika
Oct 1, 2016·Artificial Intelligence in Medicine·Alexander SeitingerKlaus-Peter Adlassnig
Nov 2, 2017·Journal of the American Medical Informatics Association : JAMIA·Sowmya VaradaRamin Khorasani
Aug 16, 2017·BMC Medical Informatics and Decision Making·Abdelali Boussadi, Eric Zapletal
Jul 30, 2020·BMJ Health & Care Informatics·David Wong, Niels Peek
May 31, 2017·Learning Health Systems·Derek CorriganBrendan Delaney
Sep 23, 2019·Journal of Biomedical Informatics·Ning ShangChunhua Weng
Jan 29, 2021·Applied Clinical Informatics·Christian MaierStefan Kraus
Dec 8, 2021·Artificial Organs·Ranjith RaveendranSameera G Nath

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