The area composita of adhering junctions connecting heart muscle cells of vertebrates. VII. The different types of lateral junctions between the special cardiomyocytes of the conduction system of ovine and bovine hearts

European Journal of Cell Biology
Sebastian PieperhoffWerner W Franke

Abstract

Postnatal development of mammalian cardiomyocytes in the working myocardium is characterized by a near-complete translocation of both kinds of adhering junctions (AJs), i.e. desmosomes and fasciae adhaerentes (FAs), to the polar intercalated disk (ID) regions where they cluster, fuse and molecularly amalgamate to extended hybrid intercellular junction structures, the area composita (composite junction; AC). Using immunofluorescence and immunoelectron microscopy we now report that the AJ structures of the conduction system, in particular those of the Purkinje fiber cells of cows and sheep are fundamentally different. Here the numerous AJs remain in lateral connections with other conductive cells. Desmosomal or desmosome-like junctions can still be distinguished from FA junctions, and a third type of AJs can be identified which shows colocalization of desmosomal and FA proteins, i.e. an AC character. These results, together with demonstrations of other cell type cytoskeletal markers such as alpha-cardiac actin and desmin, support the concept that conductive cells are derived from embryonal cardiomyocytes and are arrested at an early stage of differentiation. We also show that the conductive cells have extended plasma membrane reg...Continue Reading

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Citations

Jun 1, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Karen BiebackUNKNOWN START-MSC consortium
Oct 11, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Linda M LundMeredith Bond
Dec 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Joseph A PalatinusRobert G Gourdie
Apr 18, 2014·Cell Communication & Adhesion·Valeria MezzanoFarah Sheikh
Apr 24, 2014·Cell Communication & Adhesion·Dipal M Patel, Kathleen J Green
Oct 26, 2014·Cell and Tissue Research·Martina CaloreAlessandra Rampazzo
Apr 22, 2016·Cardiovascular Research·Valeria MezzanoFarah Sheikh
May 18, 2013·Archivos de cardiología de México·Alfredo de Micheli SerraAlberto Aranda Fraustro
Apr 11, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Elizabeth A HausnerXi Yang
Jul 18, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Manolis MavroidisConstantinos H Davos

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