PMID: 15225141Jul 1, 2004Paper

The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice

The Journal of Endocrinology
R EshetMoshe Phillip

Abstract

Sex hormones may influence longitudinal growth, either indirectly, by affecting the growth-hormone-insulin-like growth factor I (IGF-I) axis, or directly, by affecting changes within the epiphyseal growth plate (EGP). The aim of the present study was to investigate the effects of letrozole, an aromatase inhibitor, on longitudinal growth and changes in the EGP in vivo. Eighteen peripubertal male mice were divided into three groups. The first group was killed at baseline, the second was injected with letrozole (Femara) s.c., 2 mg/kg body weight/day, for 10 days, and the third was injected with the vehicle alone. Serum testosterone levels were found to be significantly higher in the treated group than in the controls. Letrozole induced a significant increase in body weight, tail length and serum growth hormone level, but had no significant effect on the level of serum IGF-I. On histomorphometric study, there was a significant increase (12%) in EGP height in the treated animals compared with controls. Immunohistochemistry showed a 3.4-fold letrozole-induced increase in the proliferation of the EGP chondrocytes, as estimated by the number of proliferation cell nuclear antigen-stained cells, and a decrease in the differentiation of t...Continue Reading

Citations

Nov 6, 2009·Journal of Bone and Mineral Metabolism·Ping ZhangHiroki Yokota
Apr 15, 2014·Arthritis Research & Therapy·Martin SchichtHorst Claassen
Dec 11, 2013·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Louise PouliotDavid A Beckman
Jun 17, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Gregg D CapponLeigh Ann Burns-Naas
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matti HeroLeo Dunkel
Nov 16, 2005·Hormone Research·Moshe Phillip, Liora Lazar
Oct 18, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·G Gat-YablonskiM Phillip
Apr 5, 2018·The Journal of Endocrinology·Majdi MasarwiGalia Gat-Yablonski
Oct 26, 2011·Nature Reviews. Endocrinology·Jan M WitSusan B Nunez
May 22, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Maria A SerratDonna King
Mar 28, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Helen KaliraiJan-M Wit
Jul 27, 2021·Animal Reproduction·Maria Angelica Machado ArroyoAntônio Chaves de Assis

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