The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

Toxins
David WilsonNorelle L Daly

Abstract

Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine, PA366, containing a hydroxyphenyl-based structure is present in the venom of several species of tarantula, and has selective toxicity against MCF-7 breast cancer cells. By contrast, a polyamine from an Australian funnel-web spider venom, which contains an identical polyamine tail to PA366 but an indole-based head-group, is only cytotoxic at high concentrations. Our results suggest that the ring structure plays a role in the cytotoxicity and that modification to the polyamine head group might lead to more potent and selective compounds with potential as novel cancer treatments.

References

May 31, 1990·Biochemical and Biophysical Research Communications·G B QuistadE W Fu
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·W S SkinnerG B Quistad
Apr 6, 2001·Cellular and Molecular Life Sciences : CMLS·T Thomas, T J Thomas
Apr 7, 2004·Toxicon : Official Journal of the International Society on Toxinology·Ian R Mellor, Peter N R Usherwood
Feb 3, 2005·Toxicon : Official Journal of the International Society on Toxinology·Kristian StrømgaardStine B Vogensen
Mar 24, 2006·Toxicon : Official Journal of the International Society on Toxinology·David Wilson, Paul F Alewood
Apr 1, 2006·Toxicon : Official Journal of the International Society on Toxinology·Pierre EscoubasGlenn F King
Apr 3, 2007·Pharmacology & Therapeutics·Márcia Renata MortariWagner Ferreira dos Santos
Sep 1, 2007·Journal of Cellular and Molecular Medicine·H J RheeJ K Lee
Sep 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Frank C SchroederJerrold Meinwald
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Jun 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Stephen T DeyrupFrank C Schroeder
Nov 10, 2011·Toxins·Natalie J SaezGlenn F King
Mar 31, 2012·Future Medicinal Chemistry·A WickendenG Erdemli
Jul 12, 2013·European Journal of Mass Spectrometry·Manuel TzourosStefan Bienz
Jun 19, 2014·Nucleic Acids Research·Ourania N KostopoulouDimitrios L Kalpaxis
Aug 13, 2014·World Journal of Clinical Oncology·Meng Zhao, Bhuvaneswari Ramaswamy
Aug 15, 2014·International Journal of Oncology·Michele LinsalataFrancesco Russo
Aug 28, 2014·BioMed Research International·Rohan A DavisSally-Ann Poulsen
Sep 30, 2014·Nature Chemical Biology·James R DoroghaziWilliam W Metcalf
Nov 19, 2014·Future Medicinal Chemistry·Sandy S PinedaGlenn F King

❮ Previous
Next ❯

Citations

Aug 14, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Anna Beatriz R MayorLibrado A Santiago
Jul 26, 2018·High-throughput·David Wilson, Norelle L Daly
Aug 6, 2020·Biomedicines·Edward R J EvansDavid T Wilson
Apr 29, 2020·ACS Chemical Neuroscience·Yvonne M ForsterAndréia Cristina Karklin Fontana

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
protein array
PCR

Software Mentioned

ProtoArray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicon : Official Journal of the International Society on Toxinology
S G CabbinessG V Odell
Toxicon : Official Journal of the International Society on Toxinology
T K ChanG V Odell
Advances in Biochemical Psychopharmacology
N KawaiT Abe
Toxicon : Official Journal of the International Society on Toxinology
S A Minton, M R Minton
© 2022 Meta ULC. All rights reserved