PMID: 18407206Jul 1, 1994Paper

The aromatic hydrocarbon receptor, dioxin action, and endocrine homeostasis

Trends in Endocrinology and Metabolism : TEM
J P Whitlock

Abstract

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin acts through the aromatic hydrocarbon (AH) receptor to enhance CYP1A1 gene transcription. There are notable mechanistic analogies between dioxin action and lipophilic hormone action. In addition, some of dioxin's adverse effects are associated with disruptions in endocrine homeostasis. Thus, dioxin biology intersects several disciplines, including toxicology, endocrinology, molecular biology, and public health.

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May 1, 1996·Reproductive Toxicology·A Lindenau, B Fischer
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