The Art of War: harnessing the epigenome against cancer

F1000Research
Jonathan NyeYamini Dalal

Abstract

Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival. Here, we focus on chaperones for the essential H3 histone variants H3.3 and CENP-A, specifically HIRA, DAXX/ATRX, DEK, and HJURP. This review summarizes recent studies elucidating their roles in regulating chromatin and discusses how cancer-specific chromatin interactions can be exploited to target cancer cells.

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Citations

Nov 13, 2019·Nucleic Acids Research·Engin DemirdizenSylvia Erhardt
Apr 8, 2020·Cell & Bioscience·Debparna NandyDebasree Dutta
May 15, 2021·Frontiers in Cell and Developmental Biology·Kim KobarJason N Berman
Aug 24, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Erwan Delbarre, Susan M Janicki

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