PMID: 1220555Dec 1, 1975Paper

The Arthus reaction in guinea-pig knee joints. A test for anti-inflammatory drugs

Agents and Actions
A BlackhamI H Shaw


A reversed passive Arthus reaction was produced in guinea-pig knee joints by intravenous injection of ovalbumin and intra-articular injection of homologous anti-ovalbumin antiserum or specific IgG2 antibody. The optimum response was obtained by varying the concentration of antigen while keeping the amount of antibody constant. Joint swelling, leucocyte infiltration in the synovial fluid and joint pathology were measured 4-6 hours and 24 hours after initiation of the reaction. The RPA lesions were almost completely inhibited by complement or polymorphonuclear leucocyte depletion. The effects of a range of drugs on the 4-6 hours response were investigated following intraperitoneal or oral administration. Cyproheptadine hydrochloride, Trasylol, indomethacin, aspirin, phenylbutazone, prednisolone sodium phosphate, chloroquine diphosphate, SKF36914 (gold triethyl phosphine), cyclophosphamide, ketoprofen, sudoxicam and naproxen all reduced one or more of the symptoms of inflammation. However, cyproheptadine was only active at high and probably non-specific dose levels. D(-)penicillamine hydrochloride and mepyramine maleate were inactive.


Feb 1, 1975·Agents and Actions·M B Goldlust, W F Schreiber
Mar 1, 1975·The Journal of Pharmacy and Pharmacology·A Blackham, R T Owen
May 1, 1973·Annals of the Rheumatic Diseases·P M Carter
Apr 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·J L Maillard, G A Voisin
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May 1, 1977·Arthritis and Rheumatism·M B GoldlustT W Harrity
Jan 1, 1985·Archives of Dermatological Research·S ImamuraS Taniguchi
Oct 1, 1977·Agents and Actions·A Blackham, H Radziwonik
Apr 1, 1979·Agents and Actions·D K GemmellA J Lewis
Oct 1, 1978·Agents and Actions·Y G Hyman, T L Vischer
Jan 1, 1983·General Pharmacology·F HertzF V DeFeudis
Jan 1, 1989·General Pharmacology·L S SudoJ Garcia-Leme
Mar 10, 2000·European Journal of Pharmacology·K KuriyamaY Abe
Feb 1, 1986·Experimental and Molecular Pathology·T TachibanaS Imamura
Jan 1, 1994·The Journal of Dermatology·Y MaekawaR Nogami

Related Concepts

Hemolytic Complement
Cavia porcellus
Injections, Intraperitoneal
Knee Joint
Differential White Blood Cell Count Procedure
Synovial Fluid

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