The Aryl Hydrocarbon Receptor and the Nervous System

International Journal of Molecular Sciences
Ludmila Juricek, Xavier Coumoul

Abstract

The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR nuclear translocator). The heterodimer is a transcription factor, which regulates the transcription of xenobiotic metabolizing enzymes. Expressed in many cells in vertebrates, it is mostly present in neuronal cell types in invertebrates, where it regulates dendritic morphology or feeding behavior. Surprisingly, few investigations have been conducted to unravel the function of the AhR in the central or peripheral nervous systems of vertebrates. In this review, we will present how the AhR regulates neural functions in both invertebrates and vertebrates as deduced mainly from the effects of xenobiotics. We will introduce some of the molecular mechanisms triggered by the well-known AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which impact on neuronal proliferation, differentiation, and survival. Finally, we will point out the common features found in mice that are exposed to pollutants, and in AhR knockout mice.

References

Sep 1, 1991·Neurotoxicology and Teratology·L L BesterveltW N Piper
Jan 1, 1989·Neurotoxicology and Teratology·S L Schantz, R E Bowman
Jul 1, 1988·Toxicology and Applied Pharmacology·D H RussellB Benson
May 1, 1995·Environmental Health Perspectives·D S HenshelK M Cheng
May 1, 1996·Neurotoxicology and Teratology·W H HannemanS H Safe
Jul 1, 1997·Environmental Health Perspectives·D S HenshelJ C DeWitt
Aug 2, 2003·Congenital Anomalies·Hiroki TeraokaTakeo Hiraga
Nov 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adrian HillAndrew Cossins
Dec 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wu DongTakeo Hiraga
May 12, 2004·Developmental Biology·Hongtao Qin, Jo Anne Powell-Coffman
Jun 1, 2004·Molecular and Cellular Biology·Cédric GouédardYannick Morel
Nov 13, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary A WilliamsonLisa A Opanashuk
Dec 16, 2004·Environmental Science & Technology·Paulo S M Carvalho, Donald E Tillitt

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Citations

Dec 12, 2019·Advances in Nutrition·Kan GaoWei-Yun Zhu
Feb 26, 2020·International Journal of Environmental Research and Public Health·Toshio SekiguchiShuichi Wada
Apr 25, 2020·International Journal of Molecular Sciences·Maria L Perepechaeva, Alevtina Y Grishanova
Dec 20, 2018·International Journal of Molecular Sciences·Necola GuerrinaCarolyn J Baglole
Nov 17, 2020·Frontiers in Genetics·Natalia BorovokMuhammad Mahajnah
Jul 30, 2020·The Science of the Total Environment·Agnieszka WnukMałgorzata Kajta
Feb 7, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Caroline Santos, Claudia Bueno Dos Reis Martinez
Mar 5, 2021·Reviews in the Neurosciences·Harish IyerArvind Kumar
Mar 21, 2021·Nature Reviews. Gastroenterology & Hepatology·Brigitta StockingerEmma Wincent
Aug 14, 2020·Environmental Toxicology and Pharmacology·Caroline Santos, Claudia Bueno Dos Reis Martinez
Apr 7, 2021·Translational Psychiatry·Ekaterina ProtsenkoOwen M Wolkowitz
Sep 25, 2020·European Journal of Medicinal Chemistry·Elizabeth Goya-JorgeRosa M Giner
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elizabeth Goya-JorgeRosa M Giner
Aug 8, 2021·International Journal of Molecular Sciences·Bryan Phillips-FarfánLuz Camacho
Aug 11, 2021·Cellular and Molecular Neurobiology·Konrad A SzychowskiAnna K Wójtowicz

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