The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related.

Genetics
A Shearn

Abstract

Mutations in the ash-1 and ash-2 genes of Drosophila melanogaster cause a wide variety of homeotic transformations that are similar to the transformations caused by mutations in the trithorax gene. Based on this similar variety of transformations, it was hypothesized that these genes are members of a functionally related set. Three genetic tests were employed here to evaluate that hypothesis. The first test was to examine interactions of ash-1, ash-2 and trithorax mutations with each other. Double and triple heterozygotes of recessive lethal alleles express characteristic homeotic transformations. For example, double heterozygotes of a null allele of ash-1 and a deletion of trithorax have partial transformations of their first and third legs to second legs and of their halteres to wings. The penetrance of these transformations is reduced by a duplication of the bithorax complex. The second test was to examine interactions with a mutation in the female sterile (1) homeotic gene. The penetrance of the homeotic phenotype in progeny from mutant mothers is increased by heterozygosis for alleles of ash-1 or ash-2 as well as for trithorax alleles. The third test was to examine the interaction with a mutation of the Polycomb gene. The ...Continue Reading

Citations

Dec 1, 1990·Trends in Genetics : TIG·R Paro
Sep 12, 2002·Trends in Molecular Medicine·Emma C Collins, Terence H Rabbitts
Mar 25, 2006·Development·Robert K Maeda, François Karch
Nov 6, 2007·Biochemical and Biophysical Research Communications·Yujiro TanakaDimitris Kioussis
Sep 17, 2004·Development·Mireia AnguloFlorenci Serras
Sep 11, 2013·The Journal of Biological Chemistry·Gang YuanBing Zhu
Mar 6, 2019·EMBO Reports·Eshagh DorafshanYuri B Schwartz
Sep 1, 1989·Molecular & General Genetics : MGG·C T WuW M Gelbart
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Charlotte GrimaudGiacomo Cavalli
May 16, 2007·Progress in Histochemistry and Cytochemistry·Lorenza González-MariscalErika Garay
Jun 5, 2007·Gene·Yujiro TanakaShigetaka Kitajima
Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hugh W Brock, Cynthia L Fisher
Dec 19, 2002·The Journal of Biological Chemistry·Assen RoguevA Francis Stewart
Sep 26, 2001·The Journal of Biological Chemistry·S O'ConnellR S Jones
May 26, 1998·Annals of the New York Academy of Sciences·J A KennisonB J Brizuela
Sep 22, 2019·G3 : Genes - Genomes - Genetics·Eshagh DorafshanYuri B Schwartz
Aug 1, 1991·Current Opinion in Genetics & Development·S Dessain, W McGinnis
Feb 3, 2016·Biochemistry·Cigall KadochHeike Keilhack
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Gellon, W McGinnis
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kristin Nastase Byrd, Allen Shearn

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