The ASPECTS template is weighted in favor of the striatocapsular region

NeuroImage
Thanh G PhanDavid C Reutens

Abstract

The extent of cerebral infarction correlates with increased risk of intracerebral hemorrhage (ICH) following recombinant tissue plasminogen activator (rt-PA) administration. The Alberta Stroke Program Early CT Score (ASPECTS) is a widely used, validated method which assesses involvement of 10 selected regions of the MCA territory. An ASPECTS score >7 is associated with a higher risk of ICH following thrombolysis than lower scores. To understand the internal structure of the ASPECTS template better, we estimated the infarct volume corresponding to each region. We hypothesized that, in the ASPECTS scoring system, the striatocapsular region is weighted disproportionally. Four experienced radiologists rated individual ASPECTS regions on subacute CT images (day 5-day 10) of 19 patients with MCA territory stroke. Infarct volume was determined from manual segmentation of infarcts on CT images. Linear regression was used to estimate the regional volume associated with each ASPECTS region. The ASPECTS regions are weighted unequally with the striatocapsular region accounting for 21% of the MCA territory infarct volume. Together, the 10 ASPECTS regions account for approximately 51% of the maximum MCA infarct territory volume. These findin...Continue Reading

References

Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·A van der ZwanM Dujovny
Mar 16, 2004·Lancet·Werner HackeUNKNOWN NINDS rt-PA Study Group Investigators
Apr 9, 2005·Stroke; a Journal of Cerebral Circulation·Thanh G PhanDavid C Reutens
Sep 17, 2005·Stroke; a Journal of Cerebral Circulation·Andrew M DemchukUNKNOWN NINDS rtPA Stroke Study Group, NIH

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Citations

Oct 18, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroyuki KawanoMakoto Uchino
Jun 7, 2011·Neuroimaging Clinics of North America·Angelos A KonstasMichael H Lev
Jul 9, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ke LinWalter E Zink
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Junya AokiKen Uchino
Sep 23, 2008·Handbook of Clinical Neurology·Gabriel R De FreitasJulien Bogousslavsky
Jun 6, 2009·Stroke; a Journal of Cerebral Circulation·Oliver C SingerUNKNOWN MR Stroke Study Group Investigators
May 5, 2007·Stroke; a Journal of Cerebral Circulation·Thanh G PhanDavid C Reutens
Nov 15, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Charlotte RossoUNKNOWN ASTER Trial and Pitié-Salpêtrière Investigators
Dec 12, 2018·Journal of Neurointerventional Surgery·Syed Ali RazaSrikant Rangaraju
Jan 28, 2017·Frontiers in Neurology·Julian Schröder, Götz Thomalla
Jul 29, 2019·Current Neurology and Neuroscience Reports·R WannamakerK Butcher
Sep 21, 2019·Stroke; a Journal of Cerebral Circulation·Pongpat VorasayanW Taylor Kimberly
Sep 7, 2017·Cerebrovascular Diseases·Mehdi BouslamaRaul G Nogueira
Jun 13, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Mehdi BouslamaRaul G Nogueira
Oct 19, 2021·Experimental and Therapeutic Medicine·Nicolae Ovidiu PopSimona Bungau

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