The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.

Eukaryotic Cell
Nadthanan PinchaiWilliam J Steinbach

Abstract

The Aspergillus fumigatus DeltapmrA (Golgi apparatus Ca(2+)/Mn(2+) P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased beta-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.

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Citations

Aug 3, 2010·Eukaryotic Cell·Daniele E EjzykowiczScott G Filler
Aug 2, 2014·PloS One·Patrícia Alves de CastroGustavo H Goldman
Dec 19, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sarita Keni, Narayan S Punekar
Sep 7, 2019·Current Protein & Peptide Science·Verónica PlazaLuis Castillo
Nov 15, 2019·Clinical Microbiology Reviews·Jean-Paul Latgé, Georgios Chamilos
Jul 23, 2021·Journal de mycologie médicale·Zeynab YassinReza Ghasemi

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