The Aspergillus nidulans snt genes are required for the regulation of septum formation and cell cycle checkpoints.

Genetics
P R Kraus, S D Harris

Abstract

In Aspergillus nidulans, germinating conidia undergo multiple rounds of nuclear division before forming a septum. Previous genetic results suggest that the ability to separate nuclear division and septum formation depends upon a threshold level of activity of the cyclin-dependent kinase NIMX(cdk1). Mutations in nimX and nimT, the gene encoding the NIMX(cdk1)-activating phosphatase, have revealed that Tyr-15 phosphorylation is important for determining the timing of the formation of the first septum. Here, we describe a screen for suppressors of nimT23 (snt), designed to identify additional components of the pathway regulating septum formation. We show that a subset of the snt mutants are defective in the temporal regulation of septum formation and in cell cycle checkpoint responses. Molecular characterization of sntA shows that it is allelic to the previously described ankA gene, which encodes the NIMX(cdk1) Tyr-15 kinase. Additional experiments described in this study show that nutritional conditions modulate the timing of septum formation and alter the phenotypes displayed by the snt mutants. A model that suggests that the timing of septum formation is influenced by DNA damage and glucose availability via the sntA and sntB ge...Continue Reading

References

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Citations

Aug 5, 2005·Genetics·Joel Fernandes LimaGustavo Henrique Goldman
Apr 4, 2002·Fungal Genetics and Biology : FG & B·Gustavo H GoldmanSteven D Harris
Nov 30, 2005·Molecular Microbiology·Cecilia Sgarlata, José Pérez-Martín
Mar 5, 2004·Fungal Genetics and Biology : FG & B·Gustavo H Goldman, Etta Kafer
May 23, 2002·FEMS Microbiology Letters·Peter R KrausSteven D Harris
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Cynthia CheliusMark R Marten

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